Effects of Venlafaxine on Chronic Neuropathic Pain Following Spinal Cord Injury
CompletedNot applicableNCT00167856
View the official record on ClinicalTrials.gov Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.
This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The purpose of this study is to evaluate the pain-relieving effects of venlafaxine hydrochloride (Effexor) in chronic neuropathic (burning, shock-like, electric) pain after spinal cord injury (SCI). Although a number of medications have been used to treat SCI pain, no drug has been consistently helpful, and, therefore, many people with SCI continue to have difficult chronic pain. Venlafaxine is a new anti-depressant drug that has not been tested for use in SCI neuropathic pain, but has been helpful for other types of neuropathic pain.
Study details
- Official title
- Effects of Venlafaxine on Chronic Neuropathic Pain Following Spinal Cord Injury
- Conditions
- Interventions
- Drug: Venalafaxine hydrochloride
- Sponsor
- US Department of Veterans Affairs
- Organization
- VA Office of Research and Development
- Start date
- 2005-06
- Primary completion
- 2007-08
- Sex
- All
- Age range
- from 18 Years to 70 Years
- Results posted
- No results posted in this snapshot
- Countries
- United States
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * participant must be able to swallow pills * fluent in English * incomplete or complete spinal cord injury * presence of at least moderately severe neuropathic pain at or below the level of injury * spinal cord injury at least 2 year prior to entering the study * pain for at least 6 months prior to entering the study * spinal cord injury level above L1 * participants on anticonvulsants are considered * approval of primary physician Exclusion Criteria: * pregnant women, or those contemplating pregnancy * prior history of use of Venlafaxine hydrochloride (Effexor) * current use of MAOI medications * persons who have a recent (past year) history of alcohol or drug abuse * persons with a history of renal disease, heart disease or uncontrolled hypertension, liver disease or hepatic cirrhosis, active major medical or psychiatric illness * persons with a significant post-traumatic encephalopathy from head trauma sustained at SCI * persons with tardive dyskinesia or narrow angle glaucoma
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT00167856