Chronic pain clinical trials in Ontario
192
Trials
25
Recruiting or not yet
334
Trial sites
27
Cities
Recruiting in Ontario
25 trials, recruiting first
All chronic pain trials in Ontario
192 trials, recruiting first
| Phase | ||||
|---|---|---|---|---|
| The Effect of Chiropractic Care on Opioid Use for Chronic Spinal Pain: A Feasibility Study NCT06160947 | Not yet recruiting | Not applicable | McMaster University | 2026-12-01 |
| Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Musculoskeletal Pain in Cerebral Palsy NCT07585292 | Not yet recruiting | Not applicable | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 2026-10-01 |
| Advancing Online Psychology Tools for Chronic Pain NCT07659873 | Not yet recruiting | Not applicable | Women's College Hospital | 2026-10 |
| Co-Adaptation of an Digital Pain Management Program for Canadian Veterans NCT07818980 | Recruiting | University Health Network, Toronto | 2026-09-14 | |
| Neurolysis for the Treatment of Medial Chronic Knee Pain Due to Osteoarthritis NCT07178951 | Recruiting | Not applicable | FUSMobile Inc. | 2026-09-09 |
| PRT for Chronic Low Back Pain NCT07696741 | Recruiting | Not applicable | University Health Network, Toronto | 2026-07-15 |
| Evaluating the Efficacy and Safety of Octane Aether for Treating Chronic Low Back Pain NCT07614568 | Not yet recruiting | Not applicable | Octane Innovation Inc. | 2026-06 |
| Advanced Brain Imaging-TKA (fMRI-TKA) NCT07464080 | Recruiting | Not applicable | Ottawa Hospital Research Institute | 2026-04-01 |
| Ketamine Assisted Psychotherapy for Treating Comorbid Chronic Pain and PTSD NCT07009158 | Recruiting | Phase 1, Phase 2 | Dr. Yuliya Knyahnytska | 2026-03-31 |
| Ecstasy to Alleviate SEvere Chronic Neuropathic Pain Trial NCT07301632 | Recruiting | Phase 2 | Unity Health Toronto | 2026-01-30 |
| Does a Virtual Program for Pelvic Pain Improve Pain and Sexual Outcomes in Individuals With Provoked Vestibulodynia? NCT06999395 | Recruiting | Not applicable | Queen's University | 2025-12-17 |
| Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND) NCT06518720 | Recruiting | Phase 2 | Centre for Addiction and Mental Health | 2025-04-01 |
| Psilocybin for Enhanced Analgesia in Chronic nEuropathic PAIN NCT06731335 | Recruiting | Phase 2 | Unity Health Toronto | 2025-03-05 |
| Longitudinal Study on Bacterial Production of LPC and LPA in Patients With Inflammatory Bowel Disease NCT06548399 | Recruiting | McMaster University | 2024-12-01 | |
| Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty NCT06123715 | Recruiting | Phase 2 | University Health Network, Toronto | 2024-04-16 |
| Emotion and Memory in Chronic Neuropathic Pain NCT06518421 | Recruiting | University Health Network, Toronto | 2024-02-12 | |
| UltrasouNd-guided Percutaneous Intercostal Nerve Cryoneurolysis for Analgesia Following Traumatic Rib Fracture NCT05865327 | Recruiting | Not applicable | Sunnybrook Health Sciences Centre | 2023-10-23 |
| Evaluating a Virtual Stepped Care Portal in Youth Awaiting Tertiary Chronic Pain Care: An Implementation-Effectiveness Hybrid Type III Study NCT05894772 | Recruiting | Not applicable | The Hospital for Sick Children | 2023-08-05 |
| RTMS and Steroid Joint Steroid Injection in Chronic Spinal Pain NCT05840354 | Recruiting | Not applicable | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 2023-06-20 |
| Power Over Pain Portal: A Stepped-care Virtual Solution to Deliver Early Intervention to Canadian Youth With Chronic Pain NCT06076889 | Recruiting | The Hospital for Sick Children | 2022-10-31 | |
| Multi-center RCT of IV Ketamine Efficacy and Safety in Chronic Daily Headaches NCT05306899 | Recruiting | Phase 3 | University Health Network, Toronto | 2022-06-01 |
| iCanCope With Post-Operative Pain (iCanCope PostOp) NCT05382962 | Recruiting | Not applicable | The Hospital for Sick Children | 2021-09-28 |
| Sacral Neuromodulation as Treatment for Chronic Constipation NCT03819062 | Recruiting | Not applicable | McMaster University | 2019-09-08 |
| Mechanisms and Outcome-Prognostication for Paresthesia-based and -Free Spinal Cord Stimulation NCT03852381 | Recruiting | Not applicable | University Health Network, Toronto | 2019-05-16 |
| Reducing Opioid Use for Chronic Pain Patients Following Surgery NCT03675386 | Recruiting | Not applicable | University Health Network, Toronto | 2018-10-15 |
| Spinal Cord Stimulation for Refractory Pain Randomized Controlled Trial: the PAcStim RCT NCT07468591 | Active, not recruiting | Not applicable | University Health Network, Toronto | 2026-09-17 |
| Pharmacogenetic Testing and Chronic Pain NCT05259865 | Suspended | Canadian Forces Health Services Centre Ottawa | 2025-09-21 | |
| 3-point vs 6-point GNRFA for Chronic KOA NCT05930756 | Withdrawn | Not applicable | McMaster University | 2025-08-09 |
| Frequency and Impact of Iron Deficiency in Pain Clinic Patients NCT06665516 | Completed | McMaster University | 2025-03-19 | |
| Feasibility Study of Combined Peripheral Nerve Block and Physiotherapy for CRPS NCT05589259 | Unknown status | Not applicable | Tracy Cupido | 2025-02-01 |
| Exploring Long-term Pain Relief with 5% Dextrose Added to Local Anesthetic NCT06617065 | Unknown status | Not applicable | The Seekers Centre | 2024-09-03 |
| Physiological Impact of Different Types of Osteoarthritis Education. NCT06400329 | Completed | Not applicable | Lisa Carlesso | 2024-08-15 |
| Augmented Reality Sensorimotor Training to Treat Chronic Neck NCT05880511 | Unknown status | Not applicable | McMaster University | 2024-03-01 |
| Online Psychology Program for Chronic Pain After Surgery NCT06455345 | Completed | Not applicable | University Health Network, Toronto | 2024-01-20 |
| Chronic Cancer Pain Management Program NCT06101849 | Completed | Not applicable | Hamilton Health Sciences Corporation | 2024-01-03 |
| Nabilone Use For Acute Pain in Inflammatory Bowel Disease Patients NCT03422861 | Unknown status | Not applicable | Samuel Lunenfeld Research Institute, Mount Sinai Hospital | 2023-12 |
| Psychotherapy for Ketamine's Enhanced Durability in Chronic Neuropathic Pain: A Randomized Controlled Pilot Trial NCT05639322 | Completed | Phase 4 | Unity Health Toronto | 2023-10-12 |
| A Study to Evaluate Efficacy and Safety of GSK3858279 in Diabetic Peripheral Neuropathic Pain NCT05838755 | Terminated | Phase 2 | GlaxoSmithKline | 2023-09-20 |
| Pain Phenotyping in Knee OA: a Pilot Trial NCT06066684 | Unknown status | University Health Network, Toronto | 2023-09-18 | |
| Superficial Parasternal Intercostal Plane Block in Cardiac Surgery Trial NCT06028126 | Completed | Not applicable | Unity Health Toronto | 2023-09-08 |
| Photo-biomodulation Therapy for Pain Relief After Caesarean Section NCT05738239 | Completed | Not applicable | McMaster University | 2023-09-01 |
| Brain MRI for Knee OA NCT05986513 | Unknown status | Not applicable | Toronto Rehabilitation Institute | 2023-09-01 |
| The Young Adult Clinic (YAC) Study NCT05147974 | Completed | Not applicable | Women's College Hospital | 2023-04-20 |
| Intra-Operative Adductor Canal Blocks NCT05601427 | Completed | Not applicable | Ottawa Hospital Research Institute | 2023-03-22 |
| A Randomized, Controlled Study of Repeat Dose Sustained Release Lidocaine for Treatment of Chronic Scrotal Pain NCT05707208 | Completed | Phase 2 | Sustained Therapeutics Inc. | 2023-03-21 |
| Aquatic Exercise for Veterans in Pain NCT05869617 | Unknown status | Not applicable | Dr. Nicholas Held | 2023-01-27 |
| Safety and Efficacy of FSD201 for the Treatment of Chronic Pain Associated With Idiopathic MCAS (MCAD) NCT05652907 | Terminated | Phase 2 | Quantum Biopharma | 2023-01-19 |
| Aging, Mobility and Chronic Low Back Pain NCT05167877 | Completed | McMaster University | 2023-01-15 | |
| Breaststroke Swimming After Breast Cancer Treatment/Surgery as a Means of Treatment for Seroma, Lymphedema, and Chronic Arm and Chest Pain NCT04080934 | Unknown status | Not applicable | Ottawa Hospital Research Institute | 2023-01-01 |
| Cryoneurolysis for TKA - a Pilot Study NCT05286996 | Unknown status | Not applicable | Unity Health Toronto | 2022-12-01 |
Cities with trial sites
- Toronto113 trials
- Hamilton41 trials
- London25 trials
- Kingston22 trials
- Sarnia11 trials
- Greater Sudbury7 trials
- Mississauga7 trials
- Newmarket6 trials
- Kitchener5 trials
- North York4 trials
- Oakville4 trials
- Barrie3 trials
- Corunna3 trials
- Markham2 trials
- Thornhill2 trials
- Waterloo2 trials
- Ajax1 trials
- Belleville1 trials
- Burlington1 trials
- Cambridge1 trials
- Hawkesbury1 trials
- Oshawa1 trials
- Scarborough Village1 trials
- St. Catharines1 trials
- Thunder Bay1 trials
- Windsor1 trials
- Woodstock1 trials
Top conditions studied in Ontario
- Chronic Pain67 trials here
- Pain17 trials here
- Pain, Chronic10 trials here
- Fibromyalgia8 trials here
- Osteoarthritis7 trials here
- Osteoarthritis, Knee6 trials here
- Insomnia6 trials here
- Low Back Pain5 trials here
- Hypertension5 trials here
- Knee Pain Chronic5 trials here
- Breast Cancer5 trials here
- Neuropathic Pain5 trials here
- Back Pain4 trials here
- Arthritis4 trials here
- Cancer4 trials here
Trial site map
Finding pain services in Ontario
Publicly funded pain services in Ontario are usually reached through a referral from a family doctor or nurse practitioner. Wait times and programs vary by region. The provincial health ministry publishes information about health services and how to find a primary care provider.
Ontario Ministry of Health(opens in a new tab)
This site does not list clinics. For more on referral routes, read finding a pain clinic in Canada.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.