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Neuropathic Pain: clinical trials and information

Neuropathic pain is pain caused by damage to, or disease of, the nervous system. People describe it with words such as burning, shooting, stabbing or electric. It can follow conditions such as diabetes, shingles, nerve injury or chemotherapy.
8
Trials with Canadian sites
1
Recruiting in Canada
163
Registry records worldwide

Neuropathic Pain clinical trials in Canada

8 trials, recruiting first
PhaseProvinces
Mechanisms and Outcome-Prognostication for Paresthesia-based and -Free Spinal Cord Stimulation
NCT03852381
RecruitingNot applicableOntarioUniversity Health Network, Toronto2019-05-16
Effects of LY3848575 Versus Placebo in Participants With Painful Distal Sensory Polyneuropathy
NCT06568042
CompletedPhase 2Eli Lilly and Company2024-08-22
Psychotherapy for Ketamine's Enhanced Durability in Chronic Neuropathic Pain: A Randomized Controlled Pilot Trial
NCT05639322
CompletedPhase 4OntarioUnity Health Toronto2023-10-12
Motor Threshold and Motor Cortex Stimulation
NCT02255643
CompletedNot applicableBritish ColumbiaUniversity of British Columbia2014-10
The Effect of Diet on Chronic Inflammation and Related Disorders Following Spinal Cord Injury
NCT02099890
CompletedPhase 3OntarioBrock University2014-09
The Role of Intravenous (IV) Lidocaine in the Management of Chronic Neuropathic Pain of Peripheral Nerve Origin
NCT01669967
CompletedNot applicableOntarioLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's2011-09
Efficacy of Perioperative Pregabalin in Reducing the Incidence of Chronic Neuropathic Pain and Postthoracotomy Syndrome.
NCT00967135
CompletedNot applicableQuebecCentre hospitalier de l'Université de Montréal (CHUM)2010-06
Safety of Intravenous Lidocaine Infusions
NCT01091935
CompletedOntarioLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's2009-06

Neuropathic Pain clinical trials worldwide (outside Canada)

155 trials, 37 recruiting or not yet recruiting. Recruiting first.

PhaseCountries
Simultaneous Engagement of Networks for Alleviating Pain (SENAP)
NCT07057206
Not yet recruitingPhase 1United StatesUniversity of Minnesota2026-11-01
SERENITY Study of Chronic Pain Interference in Adults
NCT07820475
Not yet recruitingUnited StatesUniversity of Minnesota2026-11-01
Development of a Pain Rehabilitation Program for Chronic Pain After SCI
NCT07634796
Not yet recruitingNot applicableSwedenUmeå University2026-10-01
Pediatric Electrocutaneous Analgesia for Children Experiencing Neuropathic Pain
NCT07264920
Not yet recruitingNot applicableUnited StatesJohns Hopkins University2026-10
Empowered Relief for Caregivers
NCT07636980
Not yet recruitingNot applicableUnited StatesStanford University2026-10
Virtual Reality-Based Hypnotherapy for Pain, Sleep, and Mood in Spinal Cord Injury
NCT07846410
Not yet recruitingNot applicableTurkey (Türkiye)Istanbul Physical Medicine Rehabilitation Training and Research Hospital2026-10
Evaluation of Chronic Postsurgical Pain Risk in Patients Undergoing CIED Implantation Using an AID Support System
NCT07322900
Not yet recruitingIstanbul University - Cerrahpasa2026-09-30
Evolution of Different Sensitivity Levels in Patients With Chronic Neuropathic Pain in the Pelvi-perineal Region After Treatment With High-concentration Capsaicin Patches
NCT07660510
Not yet recruitingNot applicableFranceNantes University Hospital2026-09-01
Prevalence and Risk Factors for Chronic Post-Surgical Pain Following Video-Assisted Thoracic Surgery : The EVATHO Prospective Bicentric Cohort Study.
NCT07687082
Not yet recruitingUniversity Hospital, Montpellier2026-08-01
PREDICT-DOLOR VE: Validation of a Structured Triage Protocol for Chronic Pain
NCT07696676
Not yet recruitingUniversidad Central de Venezuela2026-08-01
Ultrasound for Peripheral Nerve Modulation
NCT07572591
Not yet recruitingNot applicableUnited StatesStanford University2026-06
An Integrated Intervention of Spinal Cord Stimulation and Multidisciplinary Rehabilitation for Chronic Neuropathic Leg Pain: A Single-case Experimental Design Protocol
NCT07403331
RecruitingNot applicableNorwayOslo University Hospital2026-05-04
Virtual Reality (VR) Self-Hypnosis Software
NCT06398847
RecruitingNot applicableUnited StatesIcahn School of Medicine at Mount Sinai2026-03-26
Ultrasound Predictors of Persistent Burn Scar Pain After Blast and Drone-Related Injuries: A Prospective Cohort Study
NCT07438769
Not yet recruitingUkraineUkrainian Society of Regional Anesthesia and Pain Therapy2026-03-24
SPS Block vs. Surgical Intercostal Block for Chronic Pain After Thoracoscopic Surgery
NCT07436806
RecruitingNot applicableTurkey (Türkiye)Medipol University2026-03-01
Association of High PainDETECT Scores With Pain Region and Diagnosis in Patients Attending a Musculoskeletal and Sports Medicine Clinic
NCT07356115
RecruitingTurkey (Türkiye)Uskudar University2026-02-19
EXpain Trial - Exercise an a Non-pharmacological Pain-relieving Treatment in People With Multiple Sclerosis
NCT07342777
RecruitingNot applicableDenmarkUniversity of Aarhus2026-01-15
UDOPAL Study: Home-Based Interventional Approach to Pain Management in Home-Hospitalized Patients
NCT07265492
Not yet recruitingHospital de Manises2025-12-01
Multimodal Imaging and Biospecimen Collection for Low Back Pain (LBPB)
NCT06967363
Not yet recruitingChinaPeking University Third Hospital2025-05-15
Refining mUltiple Artificial intelliGence strateGies for Automatic Pain Assessment Investigations: RUGGI Study
NCT07038434
RecruitingNot applicableItalyValentina Cerrone2025-05-06
Efficacy of Home-delivered Transcranial Direct Electrical Stimulation or Chronic Pain
NCT07211256
RecruitingNot applicableFranceHospital Ambroise Paré Paris2025-01-09
The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSD
NCT06414356
RecruitingPhase 4United StatesMargaux M. Salas, PhD2024-10-02
PETMRI for Chronic Pain from Spinal or Peripheral Nerve Origin
NCT06599151
Not yet recruitingPhase 1Stanford University2024-10-01
Novel Stimulation Patterns to Improve the Effectiveness of Spinal Cord Stimulation
NCT05968664
RecruitingNot applicableUnited StatesAshwin Viswanathan2024-08-01
Analgesic Effectiveness of Capsaicin 8% Cutaneous Patch in Children
NCT05997979
RecruitingPhase 3FranceUniversity Hospital, Brest2024-03-05
Study of the Location of Motor Cortical Stimulation Electrodes in Chronic Neuropathic Refractory Patients
NCT06216717
RecruitingFranceCentre Hospitalier Universitaire de Nice2023-11-13
Study Evaluating the Analgesic Efficacy of Capsaicin 8% Patches in Chronic Coccygodynia.
NCT06023706
RecruitingPhase 3FranceNantes University Hospital2023-11-08
Chronic Unilateral Lumbar Radicular Pain
NCT06092749
RecruitingNot applicableEgyptAin Shams University2023-11-01
Neuronal Activation Accuracy in Closed-loop Spinal Cord Stimulation
NCT06775535
RecruitingBelgiumKarel Hanssens2023-08-02
Brain Connectivity Changes With Spinal Cord Stimulation and Treatment of Chronic Pain: A Resting State NIRS/EEG Study
NCT05811312
RecruitingUnited StatesVA Office of Research and Development2023-07-01
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
NCT05754190
RecruitingUnited StatesBrown University2023-06-20
Predictive and Impact of Pain After 6 Months of Radiotherapy, in Head and Neck Cancer
NCT05505188
RecruitingNot applicableFranceUniversity Hospital, Caen2023-03-13
Insula Neuromodulation for Chronic Neuropathic Pain
NCT05404581
RecruitingNot applicableUnited StatesUniversity of Virginia2022-11-01
Analysis of Selected Biochemical Parameters in Cerebrospinal Fluid and Peripheral Blood in the Treatment of Neuropathic Pain Using Spinal Cord Stimulation (SCS)
NCT07153211
RecruitingNot applicablePolandPawel Sokal2022-11-01
Efficacy of an Intraoperative Periradicular Application of Platelet Rich Fibrin (PRF) on the Intensity of Residual Post-surgical Neuropathic Pain After a Surgery for Disc Herniation
NCT05196503
RecruitingPhase 3FranceUniversity Hospital, Strasbourg, France2022-02-23
Diabetic Neuropathy in Spinal Cord Stimulator Patients
NCT04687215
RecruitingUnited StatesUniversity of Chicago2022-01-27
Cortical Stimulation by Direct Current for the Treatment of Chronic Pain : Pilot-study of a Stimulation Device at Home
NCT02346396
RecruitingNot applicableFranceHospices Civils de Lyon2015-02-09
Efficacy and Feasibility of BurstDR SCS in Painful Diabetic Neuropathy
NCT07250828
Enrolling by invitationNot applicableUnited StatesTriCity Research Center2025-12-15
Central Sensitisation in Nociceptive and Neuropathic Pain
NCT07321080
Active, not recruitingItalyIRCCS Centro Neurolesi Bonino Pulejo2025-12-15
Sub-threshold DRG Stimulation vs Sham in Established Responders
NCT07170722
CompletedNot applicableSwedenUmeå University2025-09-01
The Comparison of Sympathetic Blockade of Stellate Ganglion Block and Thoracic Sympathetic Ganglion Block
NCT06130514
Unknown statusNot applicableSeoul National University2024-07-10
Chronic Pain in Post-Mastectomy Patients; The Difference Between Pectoral Nerve (PECS I-II) and Erector Spinal Plane (ESP) Blocks
NCT06900842
CompletedTurkey (Türkiye)Hacettepe University2024-05-22
Eye Movement Desensitization and Reprocessing (EMDR) as a Treatment for Chronic Painful Diabetic Peripheral Neuropathy
NCT06171230
Unknown statusNot applicableNetherlandsDijklander Ziekenhuis2024-03-01
Noninvasive Modulation of Chronic Neuropathic Pain
NCT06249724
WithdrawnPhase 1, Phase 2United StatesUniversity of Utah2024-02-10
Real-World Efficacy of Evoke® Closed-loop Spinal Cord Stimulation (CL-SCS) Therapy in Chronic Pain Patients (ULTRA).
NCT06246526
Active, not recruitingNot applicableUnited StatesSaint Francis Hospital2024-01-30
High-Frequency rTMS Over the DLPFC for Chronic Low Back Pain
NCT07468799
CompletedNot applicableIndonesiaHasanuddin University2024-01-01
Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Traumatic or Post-operative Peripheral Neuropathy
NCT06071936
Unknown statusPhase 3GermanyApurano Pharmaceuticals GmbH2023-11-02
Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Central Neuropathy of Any Genesis
NCT06071949
Unknown statusPhase 3GermanyApurano Pharmaceuticals GmbH2023-11-02
Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Traumatic or Post-operative Peripheral Neuropathy
NCT06071988
Unknown statusPhase 3GermanyApurano Pharmaceuticals GmbH2023-11-02
Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Central Neuropathy of Any Genesis
NCT06072001
Unknown statusPhase 3GermanyApurano Pharmaceuticals GmbH2023-11-02

About Neuropathic Pain

What is Neuropathic Pain?

Neuropathic pain is pain caused by damage to, or disease of, the nervous system. People describe it with words such as burning, shooting, stabbing or electric. It can follow conditions such as diabetes, shingles, nerve injury or chemotherapy.

How is Neuropathic Pain usually assessed?

Clinicians usually assess neuropathic pain through a history and a neurological examination, sometimes with questionnaires designed to screen for nerve-related pain, and sometimes with nerve conduction studies or imaging.

What kinds of treatments are studied for Neuropathic Pain?

Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.

How can I find Neuropathic Pain clinical trials in Canada?

This page lists 8 registry records for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.

Related conditions

Related interventions

Related US FDA drug labels

Labels whose indications text mentions this term. US labels, not Health Canada Product Monographs.

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.