Pain: clinical trials and information
Pain clinical trials in Canada
Pain clinical trials worldwide (outside Canada)
415 trials, 33 recruiting or not yet recruiting. Recruiting first.
| Phase | Countries | ||||
|---|---|---|---|---|---|
| Prospective Randomized Study of TPS + CBT VS TPS Alone: Readmission, Opioid Use, and Chronic Pain NCT07783672 | Not yet recruiting | Not applicable | United States | M.D. Anderson Cancer Center | 2027-02-01 |
| Feasibility and Acceptability of Empowered Relief for American Indians With Pain During and After Cancer Treatment NCT07742449 | Not yet recruiting | Not applicable | United States | University of Oklahoma | 2026-10 |
| Auricular Point Acupressure for Pain NCT07852611 | Not yet recruiting | Not applicable | United States | Dan Song | 2026-10 |
| Pain and Smoking Study 2.0: A Randomized Clinical Trial of Smoking Cessation Among Veterans With Chronic Pain NCT06442514 | Recruiting | Not applicable | United States | VA Office of Research and Development | 2026-09-21 |
| Active vs. Passive VR During Office-based ENT Procedures NCT07599826 | Not yet recruiting | Not applicable | United States | Cedars-Sinai Medical Center | 2026-09 |
| A Study of Cebranopadol for Opioid Withdrawal Symptoms in Adults With Chronic Pain NCT07874620 | Not yet recruiting | Phase 2 | United States | Adneuris Therapeutics, Inc. | 2026-09 |
| Turkish Version of the Pictorial Pain Interference Questionnaire NCT07761208 | Not yet recruiting | Istinye University | 2026-08-20 | ||
| Effects of Music Therapy in Chronic Neck Pain NCT07658729 | Not yet recruiting | Not applicable | Turkey (Türkiye) | Karabuk University | 2026-07-01 |
| Mind-Body Pilates vs Pressure Biofeedback for Chronic Non-Specific Low Back Pain NCT07738965 | Not yet recruiting | Not applicable | Pakistan | Lahore University of Biological and Applied Sciences | 2026-07-01 |
| Comparison of Pain Reduction in Painful Chronic Wounds With and Without Fat Grafting NCT07480447 | Not yet recruiting | Not applicable | King Edward Medical University | 2026-05-01 | |
| Dose-Response Effects of a Brief Audio-Guided Mindfulness Intervention for Acute Pain NCT07562412 | Recruiting | Not applicable | United States | Florida State University | 2026-04-29 |
| Intraoperative Ketamine for Chronic Postoperative Pain After Open-Heart Surgery NCT07490457 | Not yet recruiting | Not applicable | Turkey (Türkiye) | Bursa City Hospital | 2026-04-15 |
| Multicomponent Care for Aromatase Inhibitor-Related Musculoskeletal Symptoms NCT07409948 | Not yet recruiting | Not applicable | Addis Ababa University | 2026-03-15 | |
| Tourniquet Exposure and Risk of Chronic Pain After Severe Limb Trauma NCT07475871 | Not yet recruiting | Ukraine | Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans) | 2026-03-15 | |
| Exploring the Feasibility of Using Virtual Reality as an Educational Tool in Chronic Pain Rehabilitation NCT07434804 | Not yet recruiting | Not applicable | Ireland | University College Dublin | 2026-02-20 |
| Chronic Pain After Combat-Related Traumatic Brain Injury (cTBI-Pain Study) A Prospective Cohort Study of Pain Chronification After Combat-Related Traumatic Brain Injury NCT07424248 | Not yet recruiting | Ukraine | Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans) | 2026-02-15 | |
| Silencing Neuroma Pain-Botulinum Toxin Versus Local Anesthetic Injection NCT07431944 | Not yet recruiting | Not applicable | Ukraine | Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans) | 2026-02-15 |
| Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia NCT06644573 | Not yet recruiting | Phase 1 | United States | Nyree Penn | 2025-11-01 |
| Oklahoma Study of Native American Pain Risk IV: Smoking Cessation and Pain NCT07080788 | Recruiting | Not applicable | United States | University of Oklahoma | 2025-09-01 |
| AuriculoTherapy NeuroImaging NCT06825390 | Recruiting | Not applicable | United States | Keith M Vogt | 2025-07-30 |
| Effects of a Protocol of Hip Flexor Stretching on Chronic Mechanical, Non-specific LBP. NCT06975345 | Not yet recruiting | Not applicable | Poland | Wroclaw University of Health and Sport Sciences | 2025-07-02 |
| Evaluation of an Opioid Stewardship Program in Non-Cancer Patients NCT07102446 | Recruiting | Not applicable | South Korea | Korea University Guro Hospital | 2025-06-27 |
| Spatiotemporal Thalamocortical Alterations Underlie Experimental and Chronic Pain NCT06968689 | Recruiting | Not applicable | United States | The University of Texas Health Science Center, Houston | 2025-06-01 |
| Efficacy of Physical Therapy Treatment in Endometriosis and Its Relationship to Adherence Rates. NCT06795243 | Recruiting | Not applicable | Spain | University of Seville | 2025-05-01 |
| Optimizing Chronic Pain Care With Mindfulness and Chronic Pain Management Visits NCT06387290 | Recruiting | Phase 3 | United States | University of Utah | 2025-02-25 |
| Effect of EMDR for Reduction of Pain Interference in Children With Sickle Cell Disease NCT07001631 | Recruiting | Not applicable | Netherlands | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 2024-09-20 |
| Brief Mindfulness Intervention for Pain Before an In-clinic Orthopedic Procedure NCT06471075 | Recruiting | Not applicable | United States | Florida State University | 2024-08-22 |
| Neural Mechanisms of Immersive Virtual Reality in Chronic Pain (VR TMD EEG) NCT06214923 | Recruiting | Not applicable | United States | University of Maryland, Baltimore | 2024-04-09 |
| A Clinical Study on the Efficacy of Cognitive Distraction Focus Relaxation Therapy Based on MR NCT06290011 | Recruiting | China | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | 2023-10-11 | |
| Implementation and Effectiveness of Mindfulness Oriented Recovery Enhancement as an Adjunct to Methadone Treatment NCT06032559 | Recruiting | Phase 3 | United States | Rutgers, The State University of New Jersey | 2023-09-04 |
| Association Between Body Composition and Pain in Spinal Cord Injury NCT05459207 | Recruiting | Not applicable | United States | University of Miami | 2023-02-20 |
| Options for Pain Management Using Nonpharmacological Strategies NCT05563792 | Recruiting | Not applicable | United States | VA Office of Research and Development | 2022-11-01 |
| AIMS Medical Outcomes Study NCT04512755 | Recruiting | United States | Advanced Integrative Medical Science Institute | 2020-07-01 | |
| Deep Breathing Relaxation and Lemongrass Aromatherapy on Pain NCT07825974 | Active, not recruiting | Not applicable | Iraq | University of Baghdad | 2026-08-11 |
| Does Patient Testimonial Improve the Pain Relief Derived From a Brief Intervention NCT07335159 | Completed | Not applicable | United States | Florida State University | 2026-01-05 |
| Effects of Mulligan SNAG in Chronic Nonspecific Low Back Pain NCT07415538 | Completed | Not applicable | Turkey (Türkiye) | Biruni University | 2026-01-05 |
| Overlapping Pelvic and Temporomandibular Pain: A Cross-Sectional Analysis of Psychosocial and Sensitization Mechanisms NCT07323797 | Completed | Spain | University of Valencia | 2025-09-09 | |
| Effects Of Aromatherapy And Reflexology On Pain, Sleep, And Satisfaction In Children With Cerebral Palsy NCT07519291 | Completed | Not applicable | Turkey (Türkiye) | Hakkari Universitesi | 2025-08-01 |
| Fibromyalgia Syndrome and Chronic Pelvic Pain NCT07344675 | Completed | Turkey (Türkiye) | Sisli Hamidiye Etfal Training and Research Hospital | 2025-07-01 | |
| Pain Reprocessing Therapy for Chronic Widespread Pain: a SCED Study NCT07050758 | Active, not recruiting | Not applicable | Norway | Oslo University Hospital | 2025-05-07 |
| Integrating Pain-CBT Into an mHealth Analgesic Support Intervention for Patients With Chronic Pain From Advanced Cancers NCT06722014 | Completed | Not applicable | United States | Dana-Farber Cancer Institute | 2025-03-27 |
| Usability of the MeTime MS App NCT07123272 | Completed | Not applicable | United States | University of Michigan | 2025-03-17 |
| Electrical Stimulation in Individuals With Chronic Neck Pain NCT06911125 | Completed | Not applicable | Turkey (Türkiye) | Afyonkarahisar Health Sciences University | 2025-03-12 |
| Comparison of Manual Therapy and Auricular Vagus Nerve Stimulation in Chronic Low Back Pain NCT06752213 | Completed | Not applicable | Turkey (Türkiye) | Istanbul Medipol University Hospital | 2025-01-06 |
| Coping Strategies with Pain Among Older People NCT06744634 | Active, not recruiting | Turkey (Türkiye) | Biruni University | 2024-12-10 | |
| Detection of Electrodermal Activity in Pain 2 NCT06677593 | Active, not recruiting | Denmark | Copenhagen University Hospital, Hvidovre | 2024-11-15 | |
| Development of STEPPT NCT06835439 | Completed | Not applicable | United States | San Diego State University | 2024-11-02 |
| The Effectiveness of Virtual Reality in the Management of Procedural Anxiety and Pain in Children Suffering From Chronic Pathologies or Burn Injuries. NCT06862830 | Active, not recruiting | Not applicable | Italy | Meyer Children's Hospital IRCCS | 2024-10-22 |
| Subthreshold Stimulation Versus Suprathreshold Stimulation in People With Chronic Low Neck Pain NCT06559358 | Unknown status | Not applicable | Beni-Suef University | 2024-09-01 | |
| Paracetamol in Addition to WHO Step III Opioids in Chronic Cancer Pain Control NCT05088876 | Terminated | Phase 4 | Switzerland | Insel Gruppe AG, University Hospital Bern | 2024-08-28 |
About Pain
What is Pain?
"Pain" is the term study registrants used on ClinicalTrials.gov. Registry labels are not always standard medical terms, and close variants of the same label appear as separate entries. In this snapshot the term appears on 434 chronic pain registry records worldwide.
How is Pain usually assessed?
Assessment of chronic pain generally involves a clinician taking a detailed history, a physical examination and, where relevant, tests to look for underlying causes. Pain rating scales and questionnaires about function, sleep and mood are often used. The approach depends on the person and the condition.
What kinds of treatments are studied for Pain?
Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.
How can I find Pain clinical trials in Canada?
This page lists 23 registry records for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.
Related interventions
- Drug: placebo (34)
- Other: Questionnaire Administration (9)
- Drug: JNJ-42160443 (8)
- Drug: Adezunap (AP707) (7)
- Procedure: psychosocial assessment and care (6)
- Drug: Oxycodone (5)
- Other: placebo (5)
- Procedure: quality-of-life assessment (5)
- Drug: pregabalin (4)
- Drug: lidocaine (4)
- Drug: Nabiximols (4)
- Drug: Cebranopadol (4)
- Other: usual care (4)
- Procedure: pain therapy (3)
- Procedure: management of therapy complications (3)
- Drug: clonidine (3)
- Drug: Buprenorphine (3)
- Procedure: fatigue assessment and management (3)
- Drug: Tapentadol Prolonged Release (3)
- Drug: GRT6005 (3)
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.