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Pain: clinical trials and information

"Pain" is the term study registrants used on ClinicalTrials.gov. Registry labels are not always standard medical terms, and close variants of the same label appear as separate entries. In this snapshot the term appears on 434 chronic pain registry records worldwide.
23
Trials with Canadian sites
2
Recruiting in Canada
434
Registry records worldwide

Pain clinical trials in Canada

23 trials, recruiting first
PhaseProvinces
UltrasouNd-guided Percutaneous Intercostal Nerve Cryoneurolysis for Analgesia Following Traumatic Rib Fracture
NCT05865327
RecruitingNot applicableOntarioSunnybrook Health Sciences Centre2023-10-23
RELIEF - A Global Prospective Observational Post-Market Study to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain
NCT01719055
RecruitingBoston Scientific Corporation2012-11-19
A Study to Evaluate Efficacy and Safety of GSK3858279 in Diabetic Peripheral Neuropathic Pain
NCT05838755
TerminatedPhase 2British Columbia, Manitoba, OntarioGlaxoSmithKline2023-09-20
Photo-biomodulation Therapy for Pain Relief After Caesarean Section
NCT05738239
CompletedNot applicableOntarioMcMaster University2023-09-01
Evaluating the Manage My Pain App in Pain Clinics
NCT05946239
CompletedNot applicableAlbertaUniversity of Alberta2023-07-10
Development and Usability Testing of a Progressive WebApp for Women With Heart Disease
NCT03800082
Unknown statusNot applicableOntarioUniversity of Toronto2021-08-01
SPRINT: Signature for Pain Recovery IN Teens
NCT04285112
Active, not recruitingOntarioStanford University2020-09-28
Pawsitive Impacts of Therapy Dog Visits
NCT04727749
CompletedNot applicableSaskatchewanUniversity of Saskatchewan2019-06-07
PECBLOCK for the Treatment of Pain After Breast Surgery
NCT01670448
CompletedNot applicableQuebecCentre hospitalier de l'Université de Montréal (CHUM)2014-01
The Effects of Mindfulness-Based Stress Reduction on Attention and Pain-related Symptoms in Chronic Pain Patients
NCT01487473
CompletedNot applicableOntarioYork University2011-12
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
NCT01431326
CompletedManitoba, Ontario, QuebecDaniel Benjamin2011-11
Methadone Hydrochloride as First-Line Therapy in Treating Patients With Chronic Neuropathic Cancer Pain
NCT00930332
TerminatedPhase 1Alberta, British Columbia, Manitoba, Ontario, QuebecNCIC Clinical Trials Group2010-06-17
A Safety and Tolerability Study of JNJ-42160443 in Patients With Moderate to Severe, Chronic Knee Pain From Osteoarthritis
NCT01094262
TerminatedPhase 2Ontario, QuebecJohnson & Johnson Pharmaceutical Research & Development, L.L.C.2010-04-20
The Effect of Soy Protein on Post- Breast Cancer Surgery Pain
NCT01047774
TerminatedPhase 2QuebecDr. Yoram Shir2010-03
A Dose-ranging Study of the Safety and Effectiveness of JNJ-42160443 as add-on Treatment in Patients With Osteoarthritis-related Pain
NCT00973141
TerminatedPhase 2British Columbia, Newfoundland and Labrador, Ontario, QuebecJohnson & Johnson Pharmaceutical Research & Development, L.L.C.2009-09-16
A Study of Sativex® for Pain Relief in Patients With Advanced Malignancy.
NCT00530764
CompletedPhase 2British Columbia, QuebecGW Pharmaceuticals Ltd2007-11
An Open-label Extension Study With Flexible Dosing of Extended-release (ER) Tapentadol (CG5503) to Treat Patients With Moderate to Severe Chronic Pain
NCT00487435
CompletedPhase 3British Columbia, Newfoundland and Labrador, Ontario, Prince Edward Island, Quebec, SaskatchewanJohnson & Johnson Pharmaceutical Research & Development, L.L.C.2007-06
Pain Relief Investigation of Neuromodulation Therapy in an Adult Fibromyalgia Population
NCT00450905
TerminatedPhase 3OntarioFralex Therapeutics2007-03
A Study to Evaluate Long-Term Safety of Multiple Doses of Tapentadol (CG5503) Prolonged-Release (PR) and Oxycodone Controlled-Release (CR) in Patients With Chronic Pain
NCT00361504
CompletedPhase 3Alberta, British Columbia, Nova Scotia, Ontario, Quebec, SaskatchewanJohnson & Johnson Pharmaceutical Research & Development, L.L.C.2006-11
[S,S]-Reboxetine Long Term Safety Study In Chronic Painful Diabetic Peripheral Neuropathy.
NCT00348894
TerminatedPhase 2Manitoba, Ontario, QuebecPfizer2006-07
A Clinical Study in Healthy Adults Who Sometimes Take Drugs for Pleasure to Investigate the Safety and Tolerability of GRT0151Y and to Find Out Which Single Dose of the Compound is Maximally Tolerated
NCT03765658
CompletedPhase 1OntarioGrünenthal GmbH2006-01-20
Use of the Cannabinoid Nabilone for the Promotion of Sleep in Chronic, Non-Malignant Pain Patients
NCT00384410
Unknown statusPhase 2OntarioUniversity Health Network, Toronto2005-12
Treatment for Chronic Pain in Patients With Advanced Cancer
NCT00003687
CompletedPhase 3Alberta, Newfoundland and Labrador, Ontario, QuebecNCIC Clinical Trials Group1998-06-11

Pain clinical trials worldwide (outside Canada)

415 trials, 33 recruiting or not yet recruiting. Recruiting first.

PhaseCountries
Prospective Randomized Study of TPS + CBT VS TPS Alone: Readmission, Opioid Use, and Chronic Pain
NCT07783672
Not yet recruitingNot applicableUnited StatesM.D. Anderson Cancer Center2027-02-01
Feasibility and Acceptability of Empowered Relief for American Indians With Pain During and After Cancer Treatment
NCT07742449
Not yet recruitingNot applicableUnited StatesUniversity of Oklahoma2026-10
Auricular Point Acupressure for Pain
NCT07852611
Not yet recruitingNot applicableUnited StatesDan Song2026-10
Pain and Smoking Study 2.0: A Randomized Clinical Trial of Smoking Cessation Among Veterans With Chronic Pain
NCT06442514
RecruitingNot applicableUnited StatesVA Office of Research and Development2026-09-21
Active vs. Passive VR During Office-based ENT Procedures
NCT07599826
Not yet recruitingNot applicableUnited StatesCedars-Sinai Medical Center2026-09
A Study of Cebranopadol for Opioid Withdrawal Symptoms in Adults With Chronic Pain
NCT07874620
Not yet recruitingPhase 2United StatesAdneuris Therapeutics, Inc.2026-09
Turkish Version of the Pictorial Pain Interference Questionnaire
NCT07761208
Not yet recruitingIstinye University2026-08-20
Effects of Music Therapy in Chronic Neck Pain
NCT07658729
Not yet recruitingNot applicableTurkey (Türkiye)Karabuk University2026-07-01
Mind-Body Pilates vs Pressure Biofeedback for Chronic Non-Specific Low Back Pain
NCT07738965
Not yet recruitingNot applicablePakistanLahore University of Biological and Applied Sciences2026-07-01
Comparison of Pain Reduction in Painful Chronic Wounds With and Without Fat Grafting
NCT07480447
Not yet recruitingNot applicableKing Edward Medical University2026-05-01
Dose-Response Effects of a Brief Audio-Guided Mindfulness Intervention for Acute Pain
NCT07562412
RecruitingNot applicableUnited StatesFlorida State University2026-04-29
Intraoperative Ketamine for Chronic Postoperative Pain After Open-Heart Surgery
NCT07490457
Not yet recruitingNot applicableTurkey (Türkiye)Bursa City Hospital2026-04-15
Multicomponent Care for Aromatase Inhibitor-Related Musculoskeletal Symptoms
NCT07409948
Not yet recruitingNot applicableAddis Ababa University2026-03-15
Tourniquet Exposure and Risk of Chronic Pain After Severe Limb Trauma
NCT07475871
Not yet recruitingUkraineCharitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)2026-03-15
Exploring the Feasibility of Using Virtual Reality as an Educational Tool in Chronic Pain Rehabilitation
NCT07434804
Not yet recruitingNot applicableIrelandUniversity College Dublin2026-02-20
Chronic Pain After Combat-Related Traumatic Brain Injury (cTBI-Pain Study) A Prospective Cohort Study of Pain Chronification After Combat-Related Traumatic Brain Injury
NCT07424248
Not yet recruitingUkraineCharitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)2026-02-15
Silencing Neuroma Pain-Botulinum Toxin Versus Local Anesthetic Injection
NCT07431944
Not yet recruitingNot applicableUkraineCharitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)2026-02-15
Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia
NCT06644573
Not yet recruitingPhase 1United StatesNyree Penn2025-11-01
Oklahoma Study of Native American Pain Risk IV: Smoking Cessation and Pain
NCT07080788
RecruitingNot applicableUnited StatesUniversity of Oklahoma2025-09-01
AuriculoTherapy NeuroImaging
NCT06825390
RecruitingNot applicableUnited StatesKeith M Vogt2025-07-30
Effects of a Protocol of Hip Flexor Stretching on Chronic Mechanical, Non-specific LBP.
NCT06975345
Not yet recruitingNot applicablePolandWroclaw University of Health and Sport Sciences2025-07-02
Evaluation of an Opioid Stewardship Program in Non-Cancer Patients
NCT07102446
RecruitingNot applicableSouth KoreaKorea University Guro Hospital2025-06-27
Spatiotemporal Thalamocortical Alterations Underlie Experimental and Chronic Pain
NCT06968689
RecruitingNot applicableUnited StatesThe University of Texas Health Science Center, Houston2025-06-01
Efficacy of Physical Therapy Treatment in Endometriosis and Its Relationship to Adherence Rates.
NCT06795243
RecruitingNot applicableSpainUniversity of Seville2025-05-01
Optimizing Chronic Pain Care With Mindfulness and Chronic Pain Management Visits
NCT06387290
RecruitingPhase 3United StatesUniversity of Utah2025-02-25
Effect of EMDR for Reduction of Pain Interference in Children With Sickle Cell Disease
NCT07001631
RecruitingNot applicableNetherlandsAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)2024-09-20
Brief Mindfulness Intervention for Pain Before an In-clinic Orthopedic Procedure
NCT06471075
RecruitingNot applicableUnited StatesFlorida State University2024-08-22
Neural Mechanisms of Immersive Virtual Reality in Chronic Pain (VR TMD EEG)
NCT06214923
RecruitingNot applicableUnited StatesUniversity of Maryland, Baltimore2024-04-09
A Clinical Study on the Efficacy of Cognitive Distraction Focus Relaxation Therapy Based on MR
NCT06290011
RecruitingChinaXinhua Hospital, Shanghai Jiao Tong University School of Medicine2023-10-11
Implementation and Effectiveness of Mindfulness Oriented Recovery Enhancement as an Adjunct to Methadone Treatment
NCT06032559
RecruitingPhase 3United StatesRutgers, The State University of New Jersey2023-09-04
Association Between Body Composition and Pain in Spinal Cord Injury
NCT05459207
RecruitingNot applicableUnited StatesUniversity of Miami2023-02-20
Options for Pain Management Using Nonpharmacological Strategies
NCT05563792
RecruitingNot applicableUnited StatesVA Office of Research and Development2022-11-01
AIMS Medical Outcomes Study
NCT04512755
RecruitingUnited StatesAdvanced Integrative Medical Science Institute2020-07-01
Deep Breathing Relaxation and Lemongrass Aromatherapy on Pain
NCT07825974
Active, not recruitingNot applicableIraqUniversity of Baghdad2026-08-11
Does Patient Testimonial Improve the Pain Relief Derived From a Brief Intervention
NCT07335159
CompletedNot applicableUnited StatesFlorida State University2026-01-05
Effects of Mulligan SNAG in Chronic Nonspecific Low Back Pain
NCT07415538
CompletedNot applicableTurkey (Türkiye)Biruni University2026-01-05
Overlapping Pelvic and Temporomandibular Pain: A Cross-Sectional Analysis of Psychosocial and Sensitization Mechanisms
NCT07323797
CompletedSpainUniversity of Valencia2025-09-09
Effects Of Aromatherapy And Reflexology On Pain, Sleep, And Satisfaction In Children With Cerebral Palsy
NCT07519291
CompletedNot applicableTurkey (Türkiye)Hakkari Universitesi2025-08-01
Fibromyalgia Syndrome and Chronic Pelvic Pain
NCT07344675
CompletedTurkey (Türkiye)Sisli Hamidiye Etfal Training and Research Hospital2025-07-01
Pain Reprocessing Therapy for Chronic Widespread Pain: a SCED Study
NCT07050758
Active, not recruitingNot applicableNorwayOslo University Hospital2025-05-07
Integrating Pain-CBT Into an mHealth Analgesic Support Intervention for Patients With Chronic Pain From Advanced Cancers
NCT06722014
CompletedNot applicableUnited StatesDana-Farber Cancer Institute2025-03-27
Usability of the MeTime MS App
NCT07123272
CompletedNot applicableUnited StatesUniversity of Michigan2025-03-17
Electrical Stimulation in Individuals With Chronic Neck Pain
NCT06911125
CompletedNot applicableTurkey (Türkiye)Afyonkarahisar Health Sciences University2025-03-12
Comparison of Manual Therapy and Auricular Vagus Nerve Stimulation in Chronic Low Back Pain
NCT06752213
CompletedNot applicableTurkey (Türkiye)Istanbul Medipol University Hospital2025-01-06
Coping Strategies with Pain Among Older People
NCT06744634
Active, not recruitingTurkey (Türkiye)Biruni University2024-12-10
Detection of Electrodermal Activity in Pain 2
NCT06677593
Active, not recruitingDenmarkCopenhagen University Hospital, Hvidovre2024-11-15
Development of STEPPT
NCT06835439
CompletedNot applicableUnited StatesSan Diego State University2024-11-02
The Effectiveness of Virtual Reality in the Management of Procedural Anxiety and Pain in Children Suffering From Chronic Pathologies or Burn Injuries.
NCT06862830
Active, not recruitingNot applicableItalyMeyer Children's Hospital IRCCS2024-10-22
Subthreshold Stimulation Versus Suprathreshold Stimulation in People With Chronic Low Neck Pain
NCT06559358
Unknown statusNot applicableBeni-Suef University2024-09-01
Paracetamol in Addition to WHO Step III Opioids in Chronic Cancer Pain Control
NCT05088876
TerminatedPhase 4SwitzerlandInsel Gruppe AG, University Hospital Bern2024-08-28

About Pain

What is Pain?

"Pain" is the term study registrants used on ClinicalTrials.gov. Registry labels are not always standard medical terms, and close variants of the same label appear as separate entries. In this snapshot the term appears on 434 chronic pain registry records worldwide.

How is Pain usually assessed?

Assessment of chronic pain generally involves a clinician taking a detailed history, a physical examination and, where relevant, tests to look for underlying causes. Pain rating scales and questionnaires about function, sleep and mood are often used. The approach depends on the person and the condition.

What kinds of treatments are studied for Pain?

Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.

How can I find Pain clinical trials in Canada?

This page lists 23 registry records for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.

Related interventions

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.