Chronic Pain: clinical trials and information
Chronic Pain clinical trials in Canada
| Phase | Provinces | ||||
|---|---|---|---|---|---|
| Virtual Reality for Pain and Well-Being in Older Adults NCT07607899 | Recruiting | Not applicable | Quebec | Laval University | 2026-09-14 |
| Co-Adaptation of an Digital Pain Management Program for Canadian Veterans NCT07818980 | Recruiting | Ontario | University Health Network, Toronto | 2026-09-14 | |
| Ketamine Assisted Psychotherapy for Treating Comorbid Chronic Pain and PTSD NCT07009158 | Recruiting | Phase 1, Phase 2 | Ontario | Dr. Yuliya Knyahnytska | 2026-03-31 |
| Accelerated Neuromodulation for Concurrent Post-Traumatic Stress Disorder (PTSD) & Chronic Pain in Veterans NCT07192536 | Not yet recruiting | Phase 4 | British Columbia | Legion Veterans Village Research Foundation | 2026-01 |
| Standardized Natural Psilocybin-assisted Psychotherapy for Tapering of Opioid Medication NCT05585229 | Recruiting | Phase 2 | British Columbia | University of British Columbia | 2025-10-27 |
| Evaluation of a Mind-Body Based Approach for Chronic Pain Treatment NCT07143396 | Not yet recruiting | Not applicable | British Columbia | University of the Fraser Valley | 2025-10 |
| Analgesia Nociception Index In Pediatric Patients With Chronic Pain NCT07145762 | Not yet recruiting | Quebec | McGill University Health Centre/Research Institute of the McGill University Health Centre | 2025-09-15 | |
| Virtual Reality and Cranial Nerve Non-invasive Neuromodulation to Improve Quality of Life for Veterans NCT07137845 | Not yet recruiting | Not applicable | Quebec | Université de Sherbrooke | 2025-09 |
| Virtual Reality and Cranial Nerve Neuromodulation to Manage Chronic Pain NCT07065396 | Not yet recruiting | Not applicable | Quebec | Université de Sherbrooke | 2025-07 |
| Music as an Adjunct to Ketamine Therapy for Chronic Pain NCT06994559 | Recruiting | Not applicable | Quebec | McGill University | 2025-06-01 |
| Comparison of the Efficacy of an Empowered Relief Single-Session Versus Standard Care for Reducing Postoperative Pain Following Elective Orthopedic Surgery: A Randomized Controlled Trial NCT07392099 | Recruiting | Not applicable | Quebec | Université de Sherbrooke | 2025-05-05 |
| Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND) NCT06518720 | Recruiting | Phase 2 | Ontario | Centre for Addiction and Mental Health | 2025-04-01 |
| Music Intervention in Chronic Pain Patients NCT06436378 | Recruiting | Not applicable | Quebec | Laval University | 2024-05-28 |
| Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty NCT06123715 | Recruiting | Phase 2 | Ontario | University Health Network, Toronto | 2024-04-16 |
| Novel Use of Probenecid to Alleviate Symptoms of Opioid Withdrawal NCT04939623 | Recruiting | Phase 2 | Alberta | University of Calgary | 2023-10-31 |
| Evaluating a Virtual Stepped Care Portal in Youth Awaiting Tertiary Chronic Pain Care: An Implementation-Effectiveness Hybrid Type III Study NCT05894772 | Recruiting | Not applicable | Nova Scotia, Ontario, Quebec, Saskatchewan | The Hospital for Sick Children | 2023-08-05 |
| A Longitudinal Study Looking at the Prevalence, Risk Factors & Consequences of Persistent Post-surgical Pain in Children NCT06354699 | Recruiting | Telethon Kids Institute | 2023-06-26 | ||
| Lemborexant vs Zopiclone vs Clonidine for Insomnia Treatment in Chronic Pain Patients NCT05618002 | Recruiting | British Columbia | Salem Anaesthesia Pain Clinic | 2022-11-08 | |
| Power Over Pain Portal: A Stepped-care Virtual Solution to Deliver Early Intervention to Canadian Youth With Chronic Pain NCT06076889 | Recruiting | Ontario | The Hospital for Sick Children | 2022-10-31 | |
| Mechanisms and Outcome-Prognostication for Paresthesia-based and -Free Spinal Cord Stimulation NCT03852381 | Recruiting | Not applicable | Ontario | University Health Network, Toronto | 2019-05-16 |
| Reducing Opioid Use for Chronic Pain Patients Following Surgery NCT03675386 | Recruiting | Not applicable | Ontario | University Health Network, Toronto | 2018-10-15 |
| Pain Clinic Provides Public Health Safety NCT06076512 | Recruiting | British Columbia | Salem Anaesthesia Pain Clinic | 2018-02-02 | |
| Characteristics of Injury Claims by Chronic Pain Patients NCT06104384 | Recruiting | British Columbia | Salem Anaesthesia Pain Clinic | 2018-01-02 | |
| Patient Education, Self-management and Physiotherapy for Chronic Temporomandibular Disorders NCT07423234 | Active, not recruiting | Not applicable | Quebec | Ciusss de L'Est de l'Île de Montréal | 2026-01-16 |
| Complex Regional Pain Syndrome: Analgesic Outcome NCT07228949 | Completed | Quebec | Ciusss de L'Est de l'Île de Montréal | 2025-11-15 | |
| Pharmacogenetic Testing and Chronic Pain NCT05259865 | Suspended | Ontario | Canadian Forces Health Services Centre Ottawa | 2025-09-21 | |
| 3-point vs 6-point GNRFA for Chronic KOA NCT05930756 | Withdrawn | Not applicable | Ontario | McMaster University | 2025-08-09 |
| Physiological Impact of Different Types of Osteoarthritis Education. NCT06400329 | Completed | Not applicable | Ontario | Lisa Carlesso | 2024-08-15 |
| Pain Education Program Optimization (PEPO) Trial NCT06174246 | Unknown status | Not applicable | Laval University | 2023-12-11 | |
| Intercostal Cryoanalgesia for Chronic Pain After VATS Lung Resection NCT05884099 | Completed | Not applicable | Quebec | Centre hospitalier de l'Université de Montréal (CHUM) | 2023-11-09 |
| Superficial Parasternal Intercostal Plane Block in Cardiac Surgery Trial NCT06028126 | Completed | Not applicable | Alberta, British Columbia, Nova Scotia, Ontario | Unity Health Toronto | 2023-09-08 |
| Brain MRI for Knee OA NCT05986513 | Unknown status | Not applicable | Ontario | Toronto Rehabilitation Institute | 2023-09-01 |
| Using Peripheral Neurostimulation to Improve Work Rehabilitation NCT05316623 | Unknown status | Not applicable | Quebec | Université de Sherbrooke | 2023-08-08 |
| The Young Adult Clinic (YAC) Study NCT05147974 | Completed | Not applicable | Ontario | Women's College Hospital | 2023-04-20 |
| A Randomized, Controlled Study of Repeat Dose Sustained Release Lidocaine for Treatment of Chronic Scrotal Pain NCT05707208 | Completed | Phase 2 | Alberta, British Columbia, Manitoba, Ontario, Quebec | Sustained Therapeutics Inc. | 2023-03-21 |
| Aquatic Exercise for Veterans in Pain NCT05869617 | Unknown status | Not applicable | Ontario | Dr. Nicholas Held | 2023-01-27 |
| Aging, Mobility and Chronic Low Back Pain NCT05167877 | Completed | Ontario | McMaster University | 2023-01-15 | |
| Improving Pain Disability With the Use of Oral Cannabinoids NCT05351905 | Completed | Not applicable | Ontario | University Health Network, Toronto | 2022-11-22 |
| Evaluation of a Pilot Shard-care Program for Patients With Chronic Pain in the Champlain-LHIN NCT03531476 | Unknown status | Not applicable | Ontario | Ottawa Hospital Research Institute | 2022-09 |
| Development and Feasibility Testing of an Advanced Practice Physiotherapy Role in Chronic Pain Management NCT05336903 | Completed | Not applicable | Ontario | Jordan Miller, PT, PhD | 2022-06-24 |
| Feasibility Study of an Online Self-management Program for Chronic Non-cancer Pain NCT05319652 | Completed | Not applicable | Quebec | CHU de Quebec-Universite Laval | 2022-06-06 |
| Palisade Lateral Branch Technique Using Multi-tined Needles for Sacro-iliac Joint Radiofrequency Ablation NCT05043961 | Terminated | Quebec | Ciusss de L'Est de l'Île de Montréal | 2022-06-01 | |
| WebMAP for Childhood Cancer Survivors NCT05241717 | Unknown status | Not applicable | Alberta | University of Calgary | 2022-06 |
| Transcranial Direct Current Stimulation in Clinical Setting to Reduce Pain in Older Workers NCT05370833 | Unknown status | Not applicable | Quebec | Université de Sherbrooke | 2022-05-15 |
| DNIC Using Deep Learning and Artificial Intelligence NCT04896827 | Suspended | Quebec | Université de Sherbrooke | 2022-04-05 | |
| Evaluating the Efficacy of Intranasal Oxytocin on Chronic Pain NCT04903002 | Active, not recruiting | Phase 2, Phase 3 | Alberta, British Columbia, Newfoundland and Labrador | Memorial University of Newfoundland | 2022-04-01 |
| Persistent Opioid Consumption After Major Abdominal Surgery and Its Determinants NCT05197465 | Completed | Quebec | Centre hospitalier de l'Université de Montréal (CHUM) | 2022-02-13 | |
| Neuromodulation Parameter Efficacy NCT04933370 | Unknown status | Not applicable | Alberta | Alberta Health Services, Calgary | 2022-02-01 |
| French Version of Fear-Avoidance Component Scale (FACS-FR) NCT05217017 | Completed | Not applicable | Quebec | Université de Sherbrooke | 2022-02-01 |
| Evaluation of a Mind-body Based Application for the Treatment of Chronic/Persistent Pain. NCT05090683 | Completed | Not applicable | British Columbia | University of the Fraser Valley | 2021-10-15 |
Chronic Pain clinical trials worldwide (outside Canada)
1838 trials, 308 recruiting or not yet recruiting. Recruiting first.
| Phase | Countries | ||||
|---|---|---|---|---|---|
| Personalizing Veteran Pain Care: Adapting Coaching Interventions to Support Maintenance of Self-Care NCT07456150 | Not yet recruiting | Phase 1 | United States | VA Office of Research and Development | 2029-01-01 |
| DockTales for Chronic Pain NCT07680894 | Not yet recruiting | Not applicable | United States | University of Maryland, Baltimore | 2027-07-17 |
| Mindfulness Therapy for Chronic Pain After Intimate Partner Violence NCT07700355 | Not yet recruiting | Not applicable | United States | Brigham and Women's Hospital | 2027-07 |
| Multicomponent Pain Self-Management in Adults With Haemophilic Arthropathy NCT07860632 | Not yet recruiting | Not applicable | Spain | Investigación en Hemofilia y Fisioterapia | 2027-03-01 |
| Nurse-Delivered Brief Pain Relief Skills Treatment in Rural Communities NCT07863375 | Not yet recruiting | Not applicable | United States | Washington State University | 2027-03-01 |
| Healing Gardens: Leveraging Serious Games to Deliver Accessible Pain-CBT and Pharmacologic Support for Patients With Advanced Cancer Managing Pain NCT07825051 | Not yet recruiting | Not applicable | United States | Dana-Farber Cancer Institute | 2027-02-13 |
| Integrated Digital Health Approach to Reduce Hazardous Alcohol Use and Chronic Pain Among Rural Populations NCT07804914 | Not yet recruiting | Not applicable | United States | Boston University Charles River Campus | 2027-02-01 |
| MBI for Pain and Sleep in Adolescents and Young Adults With Sickle Cell Disease NCT07797582 | Not yet recruiting | Not applicable | University of Illinois at Chicago | 2027-02 | |
| "Evaluation of the Efficacy of Intravenous Lidocaine on Chronic Post-operative Pain in Patients Requiring Emergency Abdominal Surgery. A Multicentre, Randomised, Controlled, Double-blind Study." NCT07869173 | Not yet recruiting | Phase 3 | France | Nantes University Hospital | 2027-01-15 |
| Neurobiology of Pain in Burn Survivors NCT07824635 | Not yet recruiting | Not applicable | Spaulding Rehabilitation Hospital | 2027-01 | |
| Turkish Version of a Scale Measuring How People View Chronic Pain NCT07861698 | Not yet recruiting | Turkey (Türkiye) | Bilecik Seyh Edebali Universitesi | 2026-12-15 | |
| Ketamine-Assisted Psychotherapy for Treatment-Resistant Depression NCT07247006 | Not yet recruiting | Phase 2 | United States | University of Rochester | 2026-12 |
| Digital Treatment for Chronic Pain and Addiction in Veterans With Opioid Use Disorder Receiving Buprenorphine NCT07361432 | Not yet recruiting | Phase 3 | United States | VA Office of Research and Development | 2026-11-02 |
| SERENITY Study of Chronic Pain Interference in Adults NCT07820475 | Not yet recruiting | United States | University of Minnesota | 2026-11-01 | |
| The Serial Mediating Roles of Pain Acceptance and Pain Self-Efficacy in the Relationship Between Concerns About Pain and Well-Being in Pain Among Individuals With Chronic Pain: A Structural Equation Modeling Study NCT07846514 | Not yet recruiting | Turkey (Türkiye) | Bilecik Seyh Edebali Universitesi | 2026-11-01 | |
| Effectiveness of Resonance Frequency Breathing Exercises in Patients With Systemic Lupus Erythematosus and Central Sensitization NCT07868289 | Not yet recruiting | Not applicable | Turkey (Türkiye) | Istanbul University - Cerrahpasa | 2026-11-01 |
| Transcranial Electrical Stimulation for Comorbid Depression and Chronic Pain NCT07334561 | Recruiting | Not applicable | China | Shanghai Mental Health Center | 2026-11 |
| Pain Resilience and Pain Self-Efficacy as Parallel Mediators of the Relationship Between Self-Critical Rumination and Pain-Specific Well-Being in Individuals With Chronic Pain: A Structural Equation Modeling Study NCT07846540 | Not yet recruiting | Turkey (Türkiye) | Bilecik Seyh Edebali Universitesi | 2026-10-31 | |
| Mindfulness-Based Cognitive Therapy Vs. the Health Enhancement Program for Chronic Pain and Early Cognitive Decline; The Feeling of Being Pilot RCT NCT07785648 | Not yet recruiting | Not applicable | United States | Massachusetts General Hospital | 2026-10-18 |
| Reducing Chronic Pain Following Cesarean Delivery NCT07799883 | Recruiting | Not applicable | United States | Stanford University | 2026-10-05 |
| Empowered Relief for Severe Pain After Cesarean Delivery During the Inpatient Period NCT07832240 | Not yet recruiting | Not applicable | United States | Stanford University | 2026-10-05 |
| Tai Chi Intervention for Geriatric Pain Syndrome NCT03705598 | Recruiting | Not applicable | United States | University of Massachusetts, Boston | 2026-10-01 |
| The Women Veteran's Health Mission NCT07608952 | Not yet recruiting | Not applicable | McGill University Health Centre/Research Institute of the McGill University Health Centre | 2026-10-01 | |
| Development of a Pain Rehabilitation Program for Chronic Pain After SCI NCT07634796 | Not yet recruiting | Not applicable | Sweden | Umeå University | 2026-10-01 |
| Perioperative Yoga Therapy and Endometriosis Surgery NCT07765680 | Not yet recruiting | Not applicable | France | University Hospital, Lille | 2026-10-01 |
| Comparing Patient-Reported Symptoms to Objective Neck Range of Motion and Physical Capacity in Women With Chronic Neck Pain. NCT07862387 | Not yet recruiting | Borna Farhoomand | 2026-10-01 | ||
| Pediatric Electrocutaneous Analgesia for Children Experiencing Neuropathic Pain NCT07264920 | Not yet recruiting | Not applicable | United States | Johns Hopkins University | 2026-10 |
| Biopsychosocial Risk Influences on the Development and Generation of Early-Onset Chronic Pain NCT07602595 | Recruiting | United States | Children's Hospital Medical Center, Cincinnati | 2026-10 | |
| Empowered Relief for Caregivers NCT07636980 | Not yet recruiting | Not applicable | United States | Stanford University | 2026-10 |
| Outcomes Registry After Ketamine Infusions for Chronic Pain: A Longitudinal Evaluation NCT07648771 | Not yet recruiting | United States | Stanford University | 2026-10 | |
| LIFU for Chronic Pain and Generalized Anxiety Disorder NCT07686354 | Not yet recruiting | Not applicable | United States | Virginia Polytechnic Institute and State University | 2026-10 |
| Feasibility and Acceptability of Empowered Relief for American Indians With Pain During and After Cancer Treatment NCT07742449 | Not yet recruiting | Not applicable | United States | University of Oklahoma | 2026-10 |
| Virtual Reality-Based Hypnotherapy for Pain, Sleep, and Mood in Spinal Cord Injury NCT07846410 | Not yet recruiting | Not applicable | Turkey (Türkiye) | Istanbul Physical Medicine Rehabilitation Training and Research Hospital | 2026-10 |
| Concurrent tDCS for Chronic Pain in Adults With Cerebral Palsy NCT07846436 | Not yet recruiting | Not applicable | Gillette Children's Specialty Healthcare | 2026-10 | |
| Evaluation of Chronic Postsurgical Pain Risk in Patients Undergoing CIED Implantation Using an AID Support System NCT07322900 | Not yet recruiting | Istanbul University - Cerrahpasa | 2026-09-30 | ||
| BurstDR Spinal Cord Stimulation Versus Sham in Established Responders NCT07779733 | Not yet recruiting | Not applicable | Sweden | Umeå University | 2026-09-30 |
| Virtual Pain Education for Spinal Cord Stimulation Patients NCT07743905 | Not yet recruiting | Not applicable | University of Arkansas | 2026-09-09 | |
| Validation of the Turkish Brief Inventory of Treatment Expectations in Chronic Pain NCT07673874 | Not yet recruiting | Turkey (Türkiye) | Hacettepe University | 2026-09-01 | |
| Turkish Adaptation of the Pain and Smoking Inventory NCT07673926 | Not yet recruiting | Turkey (Türkiye) | Hacettepe University | 2026-09-01 | |
| Full-Spectrum Cannabis Extract for Chronic Pain and Bone Health Biomarkers in Women NCT07783295 | Not yet recruiting | Phase 2 | Brazil | Associação Pan-Americana Multidisciplinar de Endocanabinologia | 2026-09-01 |
| Internet-Delivered Acceptance and Commitment Therapy (iACT) for Youth With PTSD and Chronic Pain NCT07813728 | Recruiting | Not applicable | Sweden | Skane University Hospital | 2026-09-01 |
| Harmonized Healing: Personalized Music Interventions to Address Chronic Pain in People Living With HIV NCT07214077 | Not yet recruiting | Not applicable | Brigham and Women's Hospital | 2026-09 | |
| Personalized Care Management Model (GAP-421) for Chronic Pain in Primary Care Physiotherapy NCT07451587 | Not yet recruiting | Not applicable | Spain | Universidad Autonoma de Madrid | 2026-09 |
| Analgesic Efficacy of Multisite rTMS in Fibromyalgia Patients NCT07642882 | Recruiting | Not applicable | France | Hospital Ambroise Paré Paris | 2026-09 |
| Human Pain Atlas for Sensory Neurons NCT07740681 | Not yet recruiting | King's College Hospital NHS Trust | 2026-09 | ||
| S1R Imaging-Based Cryoneurolysis in Chronic Pain NCT07768501 | Not yet recruiting | Early phase 1 | Davidzon, Guido, M.D. | 2026-09 | |
| Alexithymia, Pain Intensity, Quality of Life, and Psychological Symptoms in Chronic Coccydynia Patients Scheduled for Ganglion Impar Block NCT07828145 | Not yet recruiting | Turkey (Türkiye) | Marmara University | 2026-09 | |
| A Study of Cebranopadol for Opioid Withdrawal Symptoms in Adults With Chronic Pain NCT07874620 | Not yet recruiting | Phase 2 | United States | Adneuris Therapeutics, Inc. | 2026-09 |
| Action Observation and Motor Imagery Training in Cervical Disc Herniation NCT07781982 | Not yet recruiting | Not applicable | İrem Çetinkaya | 2026-08-25 | |
| Effect of Rebound Pain on Chronic Postsurgical Pain After Total Knee Arthroplasty NCT07511985 | Recruiting | Turkey (Türkiye) | Konya City Hospital | 2026-08-19 |
About Chronic Pain
What is Chronic Pain?
"Chronic Pain" is the term study registrants used on ClinicalTrials.gov. Registry labels are not always standard medical terms, and close variants of the same label appear as separate entries. In this snapshot the term appears on 1972 chronic pain registry records worldwide.
How is Chronic Pain usually assessed?
Assessment of chronic pain generally involves a clinician taking a detailed history, a physical examination and, where relevant, tests to look for underlying causes. Pain rating scales and questionnaires about function, sleep and mood are often used. The approach depends on the person and the condition.
What kinds of treatments are studied for Chronic Pain?
Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.
How can I find Chronic Pain clinical trials in Canada?
This page lists 134 registry records for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.
Related interventions
- Drug: placebo (73)
- Other: usual care (19)
- Other: placebo (15)
- Drug: Ketamine (13)
- Behavioral: Acceptance and Commitment Therapy (12)
- Device: Transcranial Direct Current Stimulation (tDCS) (10)
- Other: No Intervention (10)
- Device: Spinal cord stimulation (10)
- Drug: Fentanyl (9)
- Drug: morphine (9)
- Other: Questionnaire (9)
- Behavioral: Cognitive behavioral therapy (8)
- Drug: lidocaine (8)
- Device: transcranial direct current stimulation (8)
- Other: Treatment as Usual (8)
- Other: visual analog scale (8)
- Drug: Buprenorphine (7)
- Behavioral: Yoga (7)
- Other: Control (7)
- Device: Spinal Cord Stimulator (7)
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.