Pain, Chronic: clinical trials and information
Pain, Chronic clinical trials in Canada
| Phase | Provinces | ||||
|---|---|---|---|---|---|
| UltrasouNd-guided Percutaneous Intercostal Nerve Cryoneurolysis for Analgesia Following Traumatic Rib Fracture NCT05865327 | Recruiting | Not applicable | Ontario | Sunnybrook Health Sciences Centre | 2023-10-23 |
| iCanCope With Post-Operative Pain (iCanCope PostOp) NCT05382962 | Recruiting | Not applicable | Ontario | The Hospital for Sick Children | 2021-09-28 |
| Online Psychology Program for Chronic Pain After Surgery NCT06455345 | Completed | Not applicable | Ontario | University Health Network, Toronto | 2024-01-20 |
| Relieving Chronic Pain in Older Adults With Transcranial Direct Current Stimulation NCT05617027 | Unknown status | Not applicable | Quebec | Université de Sherbrooke | 2023-10-19 |
| PR-VR At-home Program During and After COVID-19 NCT04912817 | Completed | Not applicable | Ontario | The Hospital for Sick Children | 2022-09-01 |
| Clonidine is Better Than Zopiclone for Insomnia Treatment in Chronic Pain Patients NCT05277038 | Completed | British Columbia | Salem Anaesthesia Pain Clinic | 2022-03-01 | |
| Prevention of Persistent Pain With LidocAine iNfusions in Breast Cancer Surgery (PLAN) NCT04874038 | Active, not recruiting | Phase 3 | Alberta, Newfoundland and Labrador, Nova Scotia, Ontario, Quebec | University Health Network, Toronto | 2021-09-22 |
| Development and Usability Testing of a Progressive WebApp for Women With Heart Disease NCT03800082 | Unknown status | Not applicable | Ontario | University of Toronto | 2021-08-01 |
| Evaluation of a Patient-Centred, Multidisciplinary Opioid Tapering Program for Individuals With Chronic Non-Cancer Pain on Long Term Opioid Therapy NCT04902547 | Completed | Not applicable | Manitoba | University of Manitoba | 2021-05-01 |
| Cognitive Behavioural Therapy to Optimize Post-Operative Recovery Trial NCT04274530 | Completed | Not applicable | Alberta, Newfoundland and Labrador, Ontario | McMaster University | 2021-01-25 |
| SPRINT: Signature for Pain Recovery IN Teens NCT04285112 | Active, not recruiting | Ontario | Stanford University | 2020-09-28 | |
| myoActivation® for Chronic Pain in a Marginalized Population NCT04261959 | Completed | British Columbia | University of British Columbia | 2020-02-18 | |
| Intercostobrachial Nerve Sparing to Reduce Post-Surgical Pain NCT03421522 | Unknown status | Not applicable | Ontario | McMaster University | 2019-10-15 |
| Pawsitive Impacts of Therapy Dog Visits NCT04727749 | Completed | Not applicable | Saskatchewan | University of Saskatchewan | 2019-06-07 |
| Trial Applying Policy to Eliminate or Reduce Inappropriate Narcotics in the General-population NCT03400384 | Completed | Not applicable | Quebec | Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal | 2018-07-17 |
| Lidocaine Infusions for Chronic Pain in Children NCT02983682 | Completed | Phase 3 | Ontario | The Hospital for Sick Children | 2017-01 |
Pain, Chronic clinical trials worldwide (outside Canada)
337 trials, 45 recruiting or not yet recruiting. Recruiting first.
| Phase | Countries | ||||
|---|---|---|---|---|---|
| Mantram Repetition Versus Health Education for Veterans With PTSD and Chronic Pain NCT07725588 | Not yet recruiting | Not applicable | United States | VA Office of Research and Development | 2027-04-01 |
| RUTISS-Diary and RUTISS-65 Study NCT07698041 | Not yet recruiting | United Kingdom | Katherine Finlay | 2026-07-08 | |
| Person-Centred AI Support in Interdisciplinary Rehabilitation for Chronic Pain NCT07081737 | Not yet recruiting | Not applicable | Sweden | Bjorn Ang | 2026-05-01 |
| Ultrasound Guided Pecs Block and Ketamine Infusion for Preventing Chronic Pain in Patients Undergoing Breast Cancer Surgery NCT07197684 | Not yet recruiting | Not applicable | Aga Khan University | 2026-03-16 | |
| Interoceptive Awareness and Function in Adolescents With Chronic Pain NCT07325110 | Recruiting | United States | Connecticut Children's Medical Center | 2026-02-25 | |
| Home-based Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for IBS Pain NCT06847360 | Recruiting | Not applicable | United States | Yale University | 2026-01-19 |
| Butyrate and Taurine for Chronic Postsurgical Pain in Adult Cardiac Surgical Patients NCT07144033 | Not yet recruiting | Not applicable | Hong Kong | Chinese University of Hong Kong | 2026-01-01 |
| Pain Reprocessing Therapy in Post-Operative Knee Pain NCT06800209 | Recruiting | Phase 2 | United States | Weill Medical College of Cornell University | 2025-08-13 |
| Developing a Nonpharmacological Pain Intervention for Community-dwelling Older Adults With Dementia NCT06264362 | Not yet recruiting | Not applicable | United States | Drexel University | 2025-06-02 |
| The PROACTIVE Study for Black Elders NCT06512727 | Recruiting | Not applicable | United States | University of Florida | 2025-05-07 |
| Methadone Dose Monitoring With a Remote Medication Monitor NCT06837571 | Not yet recruiting | United States | Cari Health Inc. | 2025-04-26 | |
| Prescription Opioids, Brain Structure, and Cognition in Older Adults With Chronic Pain NCT06837857 | Recruiting | Phase 2 | United States | Mayo Clinic | 2025-04-16 |
| Prospective Validation Study of an E-health Tool for Patient Selection for SCS NCT06853795 | Not yet recruiting | Erasmus Medical Center | 2025-03-01 | ||
| Sleep Well Despite Persistent Pain Symptoms NCT06351839 | Recruiting | Not applicable | Norway | University of Tromso | 2025-01-01 |
| Investigation of Grip Strength, Pain and Anxiety Levels in Dentists NCT06721117 | Not yet recruiting | Hacettepe University | 2024-12-01 | ||
| Adolescent Outcomes of Post-operative Opioid EXposure NCT06350409 | Recruiting | United States | Sharon Levy | 2024-11-12 | |
| Ziconotide for Non-cancer Pain by Intrathecal Administration NCT06541184 | Recruiting | France | ESTEVE Pharmaceuticals SAS | 2024-10-30 | |
| Feasibility of Using an App for Managing Phantom Limb Pain Associated with Combat Injury in Ukraine (PAMELA) NCT06604507 | Not yet recruiting | Ukraine | Winfried Meißner | 2024-10-15 | |
| Affecting Factors for Chronic Pain After Sternotomy NCT06534372 | Recruiting | Turkey (Türkiye) | Ankara Etlik City Hospital | 2024-09-01 | |
| Assessment of Methadone Dose Taken NCT05981573 | Recruiting | United States | Cari Health Inc. | 2024-08-26 | |
| Nutrition Care in Patients Living With Chronic Pain NCT06277232 | Recruiting | Not applicable | Sweden | Linkoeping University | 2024-08-01 |
| Embo Registry; National Registry for Artery Embolization NCT06477965 | Recruiting | United States | Vascular Solutions of North Carolina | 2024-07-15 | |
| Stellate Ganglion Block for Prevention of Post Mastectomy Depression NCT06263907 | Recruiting | Not applicable | Egypt | Mansoura University | 2024-03-01 |
| MIVetsCan: Cannabidiol (CBD)-Care Trial NCT06213233 | Recruiting | Phase 2 | United States | Kevin Boehnke | 2024-02-12 |
| Evaluation of Cognitive Behavioral Therapy for Long-term Pain in Rheumatic Disease, Including Validation of AE-FS NCT06413914 | Recruiting | Not applicable | Norway | Diakonhjemmet Hospital | 2024-01-16 |
| VR and Cooled Genicular Nerve Radio Frequency Ablation for Chronic Knee Pain NCT06336447 | Recruiting | Not applicable | United States | Northwestern University | 2024-01-12 |
| Evaluating the Efficacy of the Pain Identification and Communication Toolkit NCT06168604 | Recruiting | Not applicable | United States | Weill Medical College of Cornell University | 2023-12-14 |
| Translation and Validation of the COMM and ASI-SR NCT06084520 | Recruiting | Sweden | Uppsala University | 2023-12-01 | |
| Pain AND Opioids After Surgery NCT05877157 | Recruiting | Croatia, United Kingdom | University of Aberdeen | 2023-09-25 | |
| Screening Trial for Pain Relief in Schwannomatosis (STARFISH) NCT05684692 | Recruiting | Phase 2 | United States | Massachusetts General Hospital | 2023-08-31 |
| 7 Tesla MRI Brain Imaging to Decipher Filgotinib's Mode of Analgesic Action in Rheumatoid Arthritis NCT05697159 | Recruiting | United Kingdom | NHS Greater Glasgow and Clyde | 2023-08-22 | |
| Perfusion MRI-targeted Joint Embolization for Chronic Musculoskeletal Pain of the Shoulder, Hip and Knee NCT05700682 | Recruiting | United States | Palo Alto Veterans Institute for Research | 2023-07-15 | |
| Offset Mechanisms in Evaluation of Lumbar Medial Branch Blocks NCT05961800 | Recruiting | Not applicable | United States | University of Pittsburgh | 2023-07-05 |
| Sleep, Pain and Stress in Adolescents With Persistent Pain NCT05677412 | Recruiting | Not applicable | Finland | Helsinki University Central Hospital | 2023-05-23 |
| Predictive and Impact of Pain After 6 Months of Radiotherapy, in Head and Neck Cancer NCT05505188 | Recruiting | Not applicable | France | University Hospital, Caen | 2023-03-13 |
| Comparative Effectiveness of Online 8-session CBT vs. 1-Session Empowered Relief for Chronic Pain - The PROGRESS Study NCT05612750 | Recruiting | Not applicable | United States | Stanford University | 2023-01-01 |
| Opioid-free Anaesthesia in Breast Cancer Surgery NCT06404983 | Recruiting | Not applicable | Greece | University of Ioannina | 2022-12-28 |
| Prospective Study of Sensation and Satisfaction in Cancer and Transgender Mastectomy Patients NCT06094257 | Recruiting | United States | Weill Medical College of Cornell University | 2022-02-09 | |
| Diabetic Neuropathy in Spinal Cord Stimulator Patients NCT04687215 | Recruiting | United States | University of Chicago | 2022-01-27 | |
| A Study to Reduce Persistent Post-mastectomy Pain Using Opioid-free Anesthesia NCT05146778 | Recruiting | Not applicable | South Korea | Gangnam Severance Hospital | 2021-12-16 |
| fMRI and IVCM Cornea Microscopy of CXL in Keratoconus NCT04439552 | Recruiting | United States | Boston Children's Hospital | 2021-10-04 | |
| Using Technology to Track Pain and Pain-related Outcomes NCT04267588 | Recruiting | United States | Johns Hopkins University | 2020-08-10 | |
| Pain and Weight Treatment: Development and Trial of PAW NCT04046562 | Recruiting | Not applicable | United States | Connecticut Children's Medical Center | 2019-08-14 |
| Evaluate the Impact of Targeted Physical Activity on Clinically Debilitated Dialysis Patients. NCT06374537 | Recruiting | Not applicable | United States | University of Illinois at Chicago | 2019-05-22 |
| Evaluation of the PACE/PACENET BHL Clinical Program NCT02463266 | Recruiting | United States | University of Pennsylvania | 2014-03 | |
| Efficacy and Safety of Canadá Association in the Treatment of Chronic Pain NCT05125978 | Withdrawn | Phase 2 | EMS | 2026-09 | |
| Pain-at-Work Toolkit (Definitive Trial) NCT07600892 | Enrolling by invitation | Not applicable | United Kingdom | University of Nottingham | 2026-05-11 |
| Effectiveness of the Sana Device on Fibromyalgia Symptoms NCT05394610 | Withdrawn | Not applicable | Sana Health | 2025-12 | |
| Cognitive Behavioral Therapy for Chronic Pain in Adults With Cerebral Palsy NCT06269926 | Active, not recruiting | Not applicable | United States | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | 2025-02-27 |
| Physical Activity and Percussive Massage Therapy for Reducing Pain in Older Women NCT07056335 | Completed | Not applicable | United States | University of Michigan | 2025-01-15 |
About Pain, Chronic
What is Pain, Chronic?
"Pain, Chronic" is the term study registrants used on ClinicalTrials.gov. Registry labels are not always standard medical terms, and close variants of the same label appear as separate entries. In this snapshot the term appears on 353 chronic pain registry records worldwide.
How is Pain, Chronic usually assessed?
Assessment of chronic pain generally involves a clinician taking a detailed history, a physical examination and, where relevant, tests to look for underlying causes. Pain rating scales and questionnaires about function, sleep and mood are often used. The approach depends on the person and the condition.
What kinds of treatments are studied for Pain, Chronic?
Registered studies cover medicines, medical devices (such as nerve stimulators), procedures (such as nerve blocks or injections), physical and movement therapies, psychological approaches (such as cognitive behavioural therapy), education programs and digital tools. Being studied in a trial does not mean a treatment works or is approved. The interventions listed on this page come directly from the registry records.
How can I find Pain, Chronic clinical trials in Canada?
This page lists 16 registry records for this term with at least one site in Canada, recruiting studies first. Each trial page links to the official ClinicalTrials.gov record, which lists the study contacts. Recruiting status changes often, so check the registry, and talk to your doctor before joining a study.
Related interventions
- Drug: placebo (13)
- Drug: Adezunap (AP707) (7)
- Other: usual care (6)
- Procedure: Erector spinae plane block (6)
- Drug: Ketamine (4)
- Other: placebo (3)
- Other: Pain neuroscience education (3)
- Drug: Methadone (2)
- Behavioral: Usual care (2)
- Procedure: radiofrequency (2)
- Other: exercise (2)
- Device: Ultrasound (2)
- Behavioral: Pain Education (2)
- Drug: Paracetamol (2)
- Drug: Placebo solution (2)
- Drug: Fentanyl (2)
- Other: Education (2)
- Other: Questionnaire (2)
- Drug: Remifentanil (2)
- Behavioral: Empowered Relief (2)
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status.