Epidural Clonidine for Postoperative Hyperalgesia
WithdrawnPhase 3NCT00417443
View the official record on ClinicalTrials.gov Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.
This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
We propose performing a study in which we compare the effects of bupivacaine and fentanyl with a different drug combination - bupivacaine and clonidine. The principal research questions of the study are: 1. To compare the effect of clonidine (with bupivacaine), injected into the epidural space on the extent of hyperalgesia (abnormal pain/sensitivity in the uninjured skin surrounding the operation site) in patients undergoing operations for bowel disease, with that of fentanyl (with bupivacaine). 2. To compare the effect of clonidine (with bupivacaine), injected into the epidural space on the incidence of chronic pain 6 months after surgery for bowel disease, with that of fentanyl (with bupivacaine).
Study details
- Official title
- A Study of Effect of Epidural Clonidine on Postoperative Pain Relief, Hyperalgesia and Chronic Pain in Patients Undergoing Colorectal Surgery
- Conditions
- Postoperative Hyperalgesia
- Interventions
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
- Start date
- 2007-12
- Sex
- All
- Age range
- from 18 Years to 80 Years
- Results posted
- No results posted in this snapshot
- Countries
- United Kingdom
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: 1. Age 18-80 years 2. Scheduled for elective major bowel surgery through a vertical midline incision 3. An epidural catheter for pain relief during and after the operation is required and the patient has already consented to it. 4. Good physical health or if they have any disease (e.g. heart disease, high blood pressure, asthma), it should be well controlled with medication. Exclusion Criteria: 1. Previous abdominal surgery, kidney or liver disease 2. Inability to understand or comply with the study protocol 3. Allergy to any of the study drugs 4. Failure of either placement of an epidural catheter or poor pain relief with epidural analgesia.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT00417443