Preoperative Gabapentin for Acute and Chronic Post-thoracotomy Analgesia
CompletedNot applicableNCT00588159
View the official record on ClinicalTrials.gov Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.
This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
One dose of either gabapentin or placebo will be given to patients prior to thoracotomy. Patients will also receive an epidural infusion, intravenous patient-controlled analgesia with fentanyl, oral acetaminophen and intravenous ketorolac as needed to achieve optimal analgesia. Pain ratings and supplemental medication use will be recorded for 48 hours and will also be assessed at 3 months postoperatively to determine whether the patients who received gabapentin had improved analgesia and/or required less supplemental medication than the placebo group.
Study details
- Official title
- Preoperative Gabapentin for Acute and Chronic Post-thoracotomy Analgesia: A Randomized, Double-blinded, Placebo-controlled Study
- Conditions
- Interventions
- Sponsor
- Michelle Kinney
- Organization
- Mayo Clinic
- Start date
- 2007-06
- Primary completion
- 2010-01
- Sex
- All
- Age range
- from 45 Years to 75 Years
- Healthy volunteers
- true
- Results posted
- Yes, on ClinicalTrials.gov
- Countries
- United States
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion criteria: * Age 45-75 years * Undergoing thoracotomy (lobectomy, segmentectomy, wedge resection) Exclusion criteria: * Undergoing chest wall resection, gastroesophageal surgery * Enrolled in another post-thoracotomy analgesic research protocol * Pre-existing pain syndrome * Current gabapentin or pregabalin therapy * Inability to understand the study protocol * Coagulopathy * Current use of anticoagulants * Allergy to medications on protocol * Creatinine \>1.3 * Moderate or severe aortic stenosis * Severe psychological disorders * Bacteremia, osteomyelitis, or infection at site of thoracic epidural placement * History of previous thoracotomy * Patient declines preoperative epidural catheter placement * Prisoners or other institutionalized individuals * Severe hepatic, renal or cardiovascular disorders * Women who can become pregnant
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT00588159