Association Between Focal Dystonia and Complex Regional Pain Syndrome
CompletedNCT00595439
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
This study will investigate differences among people with focal dystonia (FD), complex regional pain syndrome (CRPS) and people who have both conditions to learn more about the cause of both disorders. Participants undergo the following procedures in five visits: * Electroencephalography (EEG). Electrodes (metal discs) are placed on the scalp with an electrode cap, a paste or a glue-like substance. The spaces between the electrodes and the scalp are filled with a gel that conducts electrical activity. Brain waves are recorded while the subject lies quietly and sensory stimulation is applied to the thumb or finger. * Magnetic resonance imaging (MRI). This test uses a magnetic field and radio waves to obtain images of body tissues and organs. The patient lies on a table that can slide in and out of the scanner, wearing earplugs to muffle loud knocking and thumping sounds that occur during the scanning process. The procedure lasts about 45 minutes, during which time the patient will be asked to lie still for up to 15 minutes at a time. * Transcranial magnetic stimulation (TMS). An insulated wire coil is placed on the scalp and a brief electrical current is passed through the coil. The current induces a magnetic field that stimulates the brain. There may be a pulling sensation on the skin under the coil and a twitch in muscles of the face, arm or leg. During the stimulation, subjects may be asked to keep their hands relaxed or to contract certain muscles. * Peripheral electrical stimulation. In two experiments, TMS is combined with peripheral electrical stimulation, similar to what is used in nerve conduction studies, to the median nerve at the wrist. There may be muscle twitching. * Surface electromyography. For TMS tests and peripheral electrical stimulation, electrodes are filled with a conductive gel and taped to the skin to record the electrical activity of three muscles on the right hand. * Needle EMG. A needle is inserted into a muscle to record the electrical ac…
Study details
- Official title
- The Association Between Focal Dystonia (FD) and Complex Regional Pain Syndrome (CRPS)
- Conditions
- Focal Dystonia
- Peripheral Nervous System Disease
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
- Organization
- National Institutes of Health Clinical Center (CC)
- Start date
- 2007-12-21
- Primary completion
- 2009-10-05
- Sex
- All
- Age range
- from 18 Years to 80 Years
- Results posted
- No results posted in this snapshot
- Countries
- United States
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
* INCLUSION CRITERIA: PATIENTS WITH FOCAL DYSTONIA (ONLY): * Age 18 years or older * Presence of FD and no CRPS PATIENTS WITH CRPS (ONLY): * Age 18 years or older * Presence of CRPS and no FD PATIENTS WITH DYSTONIA AND CRPS (CRPS + DYSTONIA): * Age 18 years or older * Presence of FD and CRPS in the same limb EXCLUSION CRITERIA: * Concurrent significant medical, surgical, neurologic or psychiatric condition * Taking the following medications: anxiolytics, antipsychotics, antiparkinson, hypnotics, stimulants, and/or antihistamines * Taking antidepressants or anticonvulsants needs to be discussed specifically in each patient * Received botulinum toxin injection within 3 months of starting the protocol * For TMS: Presence of pacemaker, implanted medical pump, metal plate or metal object in skull or eye * History of seizure disorder * No known history of hearing loss * For MRI: Presence of pacemakers or other implanted electrical devices, brain stimulators, dental implants, aneurysm clips, metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner, implanted delivery pumps, or shrapnel fragments. Welders and metal workers are also at risk for injury because of possible small metal fragments in the eye of which they may be unaware. * Pregnancy.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT00595439