Changes in Inflammatory and Contractile Protein Expression in Patients With Painful Bladder Syndrome/IC.

Brief summary (from the registry)

Interstitial cystitis (IC)/chronic pelvic pain syndrome (CPPS) is a clinical syndrome of pelvic pain and/or urinary urgency/frequency in absence of a specific cause such as bacterial infection or damage to the bladder. The pathogenetic mechanisms of IC/CPPS are as yet undefined and it is largely this lack of knowledge, which precludes a systematic therapeutic approach. Experimental evidence, including results from the animal models of cystitis and the knock-out mice, indicate a participation of tachykinin receptors, especially the NK1R, in neurogenic inflammation, which is considered an important element of the IC complex. However, there is very scant information about the molecular mechanisms of IC in humans, or of the types of receptors, which participate in neurogenic inflammation. Based on our molecular biological know-how and the clinical expertise, we propose to investigate the role of the tachykinin and bradykinin receptors and their signalling partners in CPPS and bladder dysfunction in humans.

Study details

Official title

Mediators of Neurogenic Inflammation in the Urinary Tract as Key Factors in the Painful Bladder Syndrome / Interstitial Cystitis and Bladder Dysfunction

Conditions

• Overactive Bladder
• Painful Bladder Syndrome
• Chronic Pelvic Pain Syndrome
• Cystitis, Interstitial

Sponsor

Insel Gruppe AG, University Hospital Bern

Start date

2006-10

Primary completion

2010-04

Sex

All

Age range

from 18 Years

Healthy volunteers

true

Results posted

No results posted in this snapshot

Countries

Switzerland

Total sites listed

1

Eligibility criteria