Viokase 16, Viokase16 Plus Nexium and Nexium Alone

Inclusion Criteria: 1. Males and females age 18 to 75 years inclusive. Female subjects of child bearing potential or less than two years post-menopausal must use a medically acceptable form of birth control or barrier method and have a negative pregnancy test prior to entry into study. 2. History of abdominal pain associated with chronic pancreatitis 3. Evidence of chronic pancreatitis as manifested by an abnormal secretin test, calcification of the pancreas on plain film, an abnormal CT showing a dilated pancreatic duct and/or atrophy, an abnormal Endoscopicretrogradecholangeopancreatography (ERCP), or diffuse changes on Endoscopic Ultrasound (EUS), fecal elastase \> 100ug/g stool, or serum trypsinogen \> 20ng/ml \- Exclusion Criteria: 1. Subjects on enzyme therapy within the last 14 days, proton pump inhibitor (PPI)within the last 7 days, or octreotide within 48 hours. 2. Subjects with known hypersensitivity to pork or exogenous or pancreatic enzymes. 3. Female subjects who are pregnant or lactating 4. Subject use of enzyme therapy other than that called for in this study 5. Subject use of therapeutic amounts of antacids or H2 receptor antagonists during the course of the study. 6. Past history of documented steatorrhea by 72 hour fecal fat determination or current history consistent with steatorrhea -