A Study on the Effects of Ranolazine on Exercise Duration in Subjects With Chronic Stable Angina and Coronary Artery Disease (CAD) With Type 2 Diabetes Mellitus (T2DM)

Inclusion Criteria: * Written informed consent * Males and females aged 18 to 79 years * Able to perform a Sheffield Modified Bruce Treadmill Exercise Protocol * At least a 3-months history of chronic stable angina triggered by physical effort and relieved by rest and/or sublingual nitroglycerin * Coronary artery disease documented by one or more of the following: * Angiographic evidence of ≥ 50% stenosis of one or more major coronary arteries * History of myocardial infarction (MI) documented by positive CK-MB enzymes, troponins, or ECG changes * Cardiac nuclear scan studies diagnostic of CAD, e.g., thallium scan or ECHO with stress or pharmacologic interventions (adenosine, dipyridamole, etc.) * Stable treatment with one of the following antianginal medications for at least 4 weeks prior to Screening: * beta-blocker (atenolol up to 50 mg daily or metoprolol up to 100 mg daily) * dihydropyridine calcium-channel blocker (amlodipine up to 5 mg daily or nifedipine up to 30 mg daily) * non-dihydropyridine calcium-channel blocker (diltiazem 180 to 360 mg daily or verapamil 180 to 360 mg daily) * Willingness to discontinue other antianginals and be treated with one of the allowed antianginal therapies * Documented history of type 2 diabetes mellitus * Females of childbearing potential must agree to utilize highly effective contraception methods from Screening throughout the duration of study treatment and for 14 days following the last dose of study drug. Exclusion Criteria: * Inability to exercise or having exercise limitation due to other co-morbidities that may interfere with ability to perform required ETT (e.g., morbid obesity, significant chronic lung disease, prior hospitalization for acute exacerbation of chronic lung disease or home oxygen use, chronic oral steroid therapy that can limit exercise capacity, osteoarthritis, peripheral artery disease, etc.) * Any absolute contraindication to ETT * Presence of electrocardiographic or other abnormalities that interfere with ECG interpretation or may cause a false positive stress test (e.g., ≥ 1 mm horizontal or down-sloping ST segment depression at rest in any standard ECG lead, Lown-Ganong-Levine syndrome, Wolff-Parkinson-White syndrome, left bundle branch block, left ventricular hypertrophy with repolarization abnormality, ventricular pacemaker, etc.) * Decompensated heart failure * Clinically significant valvular heart disease or congenital cardiac defects * Acute coronary syndrome in the prior 2 months …