Neocartilage Implant to Treat Cartilage Lesions of the Knee

Inclusion Criteria: Generally, the following inclusion criteria must be met, however, this is not a complete list. * Male or Female between the ages of 18 and 60 * (1) or (2) articular cartilage lesions of the distal femur ranging in no more than 5 cm2 each * Ipsilateral knee compartment has intact menisci (or meniscectomized remnant with \> 5mm wide rim) and stable ligaments in the affected knee * 3 months out from initiation of conservative non-surgical management (e.g.hyaluronic acid injection, activity modification) or previous minimal surgical intervention (e.g., arthroscopic lavage, debridement) or 12 months out from marrow stimulation for this condition Exclusion Criteria: Generally, if a potential participant meets any of the following criterions, they will not be eligible for this study. Additionally, more criteria will be evaluated to confirm eligibility as this list is not a complete list of criteria. * Osteoarthritis * Rheumatoid arthritis * History of septic or reactive arthritis * Gout or a history of gout or pseudo-gout in the affected knee * Osteochondritis dissecans or osteochondral lesions of the knee with bone loss \> 6mm deep * Bipolar articular cartilage involvement (or kissing lesions) of the ipsilateral compartment (i.e., \> than ICRS Grade 2 on the opposing articular surface) * Associated damage to the underlying subchondral bone requiring an osteochondral graft * Is pregnant or breast-feeding * Has a BMI \> 35 (kg/m2) * Has prior total meniscectomy of either knee * Has received, within the past three months, intra-articular hyaluronic acid therapy, or steroid therapy * Has more than two clinically relevant chondral lesion(s) on the index knee