Unraveling the Nature of Impaired Pain Inhibition in Patients With Chronic Whiplash-associated Disorders
CompletedNCT01601912
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The primary study aim is to unravel the nature of impaired pain inhibition during exercise in patients with chronic Whiplash-Associated Disorders (WAD). This will be ascertained by examining whether activation of serotonergic and/or noradrenergic descending pathways improves pain inhibition during exercise in these patients. In addition, it is aimed at examining whether activation of serotonergic and/or noradrenergic descending pathways prevents post-exertional malaise following submaximal exercise in chronic WAD patients. A secondary study aim comprises of examining the effect of an acute submaximal exercise with and without activation of serotonergic or noradrenergic descending pathways on chronic WAD patients' cognitive performance. Furthermore, the isolated effect of activated serotonergic and noradrenergic descending pathways on chronic WAD patients' cognitive performance will be studied.
Study details
- Official title
- Unraveling the Nature of Impaired Pain Inhibition in Patients With Chronic Whiplash-associated Disorders: a Randomized Controlled Clinical Trial for the Treatment of Central Sensitization
- Conditions
- Whiplash Injuries
- Interventions
- Drug: Atomoxetine
- Drug: Citalopram
- Sponsor
- Vrije Universiteit Brussel
- Start date
- 2013-02
- Primary completion
- 2013-12
- Sex
- All
- Age range
- from 18 Years to 65 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- Belgium
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria for patients: * WAD grades I to III according to the Quebec Task Force criteria * experienced a whiplash trauma at least three months ago * with chronic pain as a result of a whiplash injury * 18-65 years of age and with Dutch as their native language will be able to participate Exclusion Criteria for patients: * other comorbidities or health issues that could explain the pain complaints * \< 18years \> 65 years * pregnant or until 1 year postnatal (for women) * use of anti-depressive, anti-epileptic and pain medication. Inclusion Criteria for healthy volunteers: * 18-65 years of age and with Dutch as their native language will be able to participate * having a sedentary job and doing \< 3 h moderate physical activity/week * being painfree without any chronic disease Exclusion Criteria for healthy volunteers: * \< 18years \> 65 years * pregnant or until 1 year postnatal (for women) * use of anti-depressive, anti-epileptic and pain medication.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT01601912