Efficiency and Safety Study of Pamidronate in Inflammatory Back Pain Due to Degenerative Disk Disease
Unknown statusPhase 2NCT01799616
View the official record on ClinicalTrials.gov Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.
This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The purpose of this study is to determine whether pamidronate is effective and well-tolerated in the treatment of painful degenerative disk disease, also known as Modic type 1 changes
Study details
- Conditions
- Intervertebral Disc Degeneration
- Modic I Discopathy
- Back Pain
- Low Back Pain
- Magnetic Resonance Imaging (MRI)
- Interventions
- Drug: Pamidronate
- Other: Placebo
- Sponsor
- University Hospital, Clermont-Ferrand
- Collaborators
- INSERM CIC 501
- Start date
- 2013-01
- Primary completion
- 2015-01
- Sex
- All
- Age range
- from 18 Years to 60 Years
- Results posted
- No results posted in this snapshot
- Countries
- France
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * \- Age from 18 to 60 years old * Low back pain * Daily pain since at least 3 months * VAS for pain \> 40/100 during the last 48 hours * Inefficiency, intolerance, or contraindication to NSAIDS * Inefficiency of a rigid or half-rigid back brace * Modic 1 discopathy (diagnosed on MRI and confirmed by trained radiologist) * Dental check-up within the last 6 months * Signed informed consent Exclusion Criteria: * \- Static disorders of the spine * Contraindication to pamidronate (hypocalcemia, severe kidney failure, or allergy) * Underage patients, patients under the protection of the law * Previous treatment with bisphosphonates * Pregnancy * Local or general infection * Previous discal surgery * Systemic corticosteroid therapy in the last month * Epidural or facet joint corticosteroid injection in the last month * History of septic spondylodiscitis * Ankylosing spondylitis * Low back pain associated with radiculalgia * Active psychiatric disorder * Inability to read or understand French * Body temperature above 38°C (fever) or Erythrocyte Sedimentation Rate above 20mm/hour
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT01799616