Risk Factors in the Initial Presentation of Specific Cardiovascular Disease Syndromes

Brief summary (from the registry)

Cardiovascular disease (CVD) is an important public health problem that affects millions of people worldwide. Associations between risk factors, such as smoking, dyslipidaemia or hypertension, and prevalent CVD are well documented. However, few studies have investigated associations with onset of disease. The initial manifestation of CVD, for example an episode of unstable angina, is important because it influences the prognosis, the quality of life and the management of disease. Furthermore, the extent to which social deprivation, alcohol consumption or atrial fibrillation affects presentation of CVD is poorly understood and deserves further consideration. Most previous studies have considered CVD as a single entity. However, differences in aetiology between coronary phenotypes suggest that risk factors may not be shared across specific coronary phenotypes and their relative importance is likely to differ for each phenotype. Gaining knowledge of these differences could provide insights into the pathophysiology of specific forms of CVD and could eventually lead to modification of recommendations for patient management and disease prevention. We propose to use the linkage of the national registry of coronary events to general practice records in the Clinical Practice Research Database (CPRD), to investigate whether demographic, behavioral, and clinico-metabolic risk factors differentially influence the onset of specific types of CVD.

Study details

Official title

Cardiovascular Risk Factors in the Initial Presentation of Specific Cardiovascular Disease Syndromes: a CALIBER Proposal Using Linked GPRD-MINAP-HES Data

Conditions

• Heart Diseases
• Cardiovascular Diseases
• Acute Myocardial Infarction
• Unstable Angina
• Chronic Stable Angina
• Ischemic Stroke
• Cerebrovascular Accident
• Subarachnoid Hemorrhage
• Transient Ischemic Attack
• Abdominal Aortic Aneurysm
• Peripheral Arterial Disease
• Sudden Coronary Death
• Ventricular Arrhythmia
• Sudden Death
• Cardiac Arrest
• Heart Failure

Sponsor

University College, London

Start date

1997-01

Primary completion

2010-03

Sex

All

Age range

from 30 Years

Healthy volunteers

true

Results posted

No results posted in this snapshot

Total sites listed

0

Eligibility criteria