Effectiveness Trial for Evaluating IAHA for PFPS

Inclusion Criteria: * Adults from the ages of 18-40, male or female * Diagnosis of unilateral OR bilateral patellofemoral pain syndrome * Duration of diagnosis no less than 2 months and no greater than 3 years in the study knee * Unresponsive to standard treatment of at least 6 weeks duration, consisting of physical therapy, activity modification (relative rest), and/or oral analgesic therapy * Insidious onset of symptoms unrelated to a traumatic incident * Pain described as "behind", "underneath", or "around" the patella reported during at least two of the following activities: * Going up or down stairs * Squatting * Running * Hopping or jumping * Kneeling * Prolonged sitting * A baseline activity related VAS pain score between 50 and 90 Exclusion Criteria: * Any co-morbidity that would influence the safety of intra-articular injections or impede safety and efficacy measurements in the study knee, such as: * Coagulopathies or the use of anticoagulant medications * History of allergy to any of the treatment interventions planned * Acute inflammation and/or palpable effusion in the study knee * Current or history of musculoskeletal infection in the study knee * Severe malalignment, deformity or chronic subluxation of study knee * History of prior patellar dislocation of the study knee * Ipsilateral joint/limb conditions (e.g. hip, thigh, lower leg, ankle, foot) * Any condition other than PFPS in the contralateral knee present at the time of enrollment or developing during the course of enrollment * Any radiographic signs of the following: * Osteoarthritis in any of the study knee compartments * Osteochondritis dissecans (OCD) lesions * Physeal injuries * Bone tumors * Vulnerable subjects and pregnant women * Participation in any other musculoskeletal studies