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Muscle Strength Loss and Its Effect on Knee Cap Motion in Volunteers With Anterior Knee Pain

CompletedNCT01862731
View the official record on ClinicalTrials.gov

Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.

This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.

Brief summary (from the registry)

Background: \- Researchers are interested in how the muscles affect the movement of the knee cap. These muscles may be related to different kinds of knee pain that are not caused by an injury or a disease. Imaging studies such as magnetic resonance imaging (MRI) can be used to look at these muscles. To study these muscles and how they move, researchers will use MRI to look at healthy individuals and individuals with knee cap pain. Objectives: \- To study how changes to the muscles around the knee can influence knee pain. Eligibility: * Individuals between 18 to 55 years of age who have knee cap pain that cannot be explained by a specific injury or disease. * Healthy volunteers between 18 and 55 years of age. Design: * Participants will be screened with a physical exam and medical history. * This study requires two visits. Each visit will use standard MRI sequences to take images of the knee in motion and at rest. * On the first visit, the MRI scan will look at the knee in its natural state. Participants will move the knee up and down for 1 to 3 minutes at a time during the scan. * On the second visit, a local anesthetic agent will be injected into the muscle of the thigh. The anesthetic will block this muscle from generating force for 2 or 3 hours. Participants will move the knee up and down for 1 to 3 minutes at a time during the MRI scan.

Study details

Official title
Vasti Control of Patellofemoral Kinematics in Patients With Chronic Patellofemoral Pain.
Conditions
  • Patellofemoral Pain Syndrome
Sponsor
National Institutes of Health Clinical Center (CC)
Start date
2013-05-31
Primary completion
2024-07-19
Sex
All
Age range
from 18 Years to 55 Years
Results posted
No results posted in this snapshot
Countries
United States
Total sites listed
1

Eligibility criteria

Show eligibility criteria (verbatim from the registry)
* INCLUSION CRITERIA: 1. Male and female volunteers between the ages of 18 and 55 EXCLUSION CRITERIA: All Volunteers 1. Any relevant medical problems, including 933 those preventing ambulation 2. Any serious injury to the joint being studied, previous surgery on the joint being studiedor extreme pain at the joint being studied or other condition that may explain the presence of PF\_pain (e.g., meniscal tear, arthritis) 3. Allergy/hypersensitivity to any local anesthetic agent (e.g., Novocain, lidocaine, bupivacaine, ropivacaine) 4. Liver disease 5. Open angle glaucoma 6. Cardiac arrhythmias, congenital heart disease 7. Glucose-6-phosphate dehydrogenase deficiency 8. Any female who is pregnant A volunteer will be excluded if they have a contraindication to MR imaging. Examples are: 1. Metal within their body, which might be expected to concentrate radiofrequency fields or cause tissue damage from twisting in a magnetic field (e.g., aneurysm clip, implanted neural stimulator, implanted cardiac pacemaker or autodefibrillator, cochlear implant, other foreign body (e.g. metal shavings, insulin pump). 2. A condition, which would preclude them from participating in an MR imaging study (e.g., paralyzed hemidiaphragm, morbid obesity, severe claustrophobia) 3. A condition that presents an unnecessary risk to them or their unborn child (e.g., 953 pregnancy, previous surgery of uncertain type, symptoms of pheochromocytoma or insulinoma) Subjects with Chronic Idiopathic Patellofemoral Pai: 1\. Lack of PF\_pain (either no active pain or current pain of \< 6 months duration) Control Volunteers: 1. Any clinical signs of a knee impairment in the joint being studied, including abnormal range of motion, muscle weakness, malalignment, and ligament damage. 2. The presence of PF\_pain (either active or past)

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT01862731