CORAL - Cebranopadol Versus Morphine Prolonged-release in Patients With Chronic Moderate to Severe Pain Related to Cancer

Inclusion Criteria: 1. Signed informed consent. 2. Negative pregnancy test before first dose. 3. Female and male participants willing to use acceptable and highly effective methods of birth control. 4. The following criteria must be fulfilled by participants: 1. Require daily analgesia for their pain, 2. Diagnosed with active cancer, 3. Receiving daily opioid treatment at doses not higher than 90 mg oral morphine or its equivalent (World Health Organization Step II and Step III analgesics) for an appropriate length of time, 4. Participants must be dissatisfied with their current pain treatment, 5. Participants must be suffering from cancer-related but not cancer therapy-related chronic pain for a period of 4 weeks or more prior to enrollment. 5. Eastern Cooperation Oncology Group (ECOG) score 2 or below. 6. Average pain intensity over the last 24 hours of 5 or more calculated from the pain assessments recorded during the last 3 days prior to randomization. 7. Compliance with the use of the electronic diary defined as at least 3 out of 4 of the 24 hour Numerical Rating Scale entries available during the last 4 days prior to and including the day of allocation to treatment. Exclusion Criteria: 1. Evidence of ongoing alcohol and or drug abuse and/or a history of alcohol and/or drug abuse within the last 2 years. 2. A clinically significant disease other than cancer which in the investigator's opinion may affect efficacy or safety assessments e.g., significant unstable cardiac, vascular, pulmonary, gastrointestinal, endocrine, neurological, infectious disease, psychiatric (resulting in disorientation, memory impairment or inability to report accurately) or metabolic disorders. 3. Any gastrointestinal disorder that could affect the absorption and/or elimination of Investigational Medicinal Product. 4. Any planned major surgery during the trial. 5. Known to or suspected of not being able to comply with the trial protocol and the use of Investigational Medicinal Product. 6. History of seizure disorder and/or epilepsy or any condition associated with a significant risk of seizure or epilepsy. 7. Known history and/or presence of cerebral tumor or cerebral metastases. 8. Moderate to severe hepatic impairment corresponding to Child-Pugh classification B and C. Impaired hepatic cellular integrity indicated by aspartate transaminase or alanine transaminase greater than 3 times the upper limit of normal at the Enrollment Visit. 9. Inadequate baseline bone marrow reserve…