Chronic Pain and Vitamin D
Unknown statusNot applicableNCT02002000
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Non-systematized chronic musculoskeletal pains are a frequent reason for consulting in general practice. The possible causes are numerous and sometimes nonspecific. In some cases, the etiologic investigation of patients with non-systematized and chronic musculoskeletal pain can not highlight any organic cause. Several studies have shown a link between these symptoms and vitamin D deficiency, characterized by a blood level of 25 (OH) vitamin D \< 20.8ng/ml. This deficit is easy to identify and to correct through proper vitamin D supplementation with few side effects. Nevertheless, it remains unknown and vitamin D deficiency is rarely considered as a possible etiology in patients with chronic pain. We hypothesize that vitamin D supplementation in patients with non-systematized musculoskeletal pain and deficient in vitamin D could improve painful symptoms. We aim to perform a double-blind randomized controlled trial, vitamin D versus placebo, to assess the pain improvement after vitamin D supplementation.
Study details
- Official title
- Chronic Pain and Vitamin D: a Randomized Pilot Study in General Practice
- Conditions
- Chronic Musculoskeletal Pain
- Vitamin D Supplementation
- Interventions
- Drug: vitamin D (cholecalciferol)
- Drug: Placebo, similar in appearance and taste to cholecalciferol
- Sponsor
- Hospices Civils de Lyon
- Start date
- 2013-12
- Primary completion
- 2014-05
- Sex
- All
- Age range
- from 18 Years to 50 Years
- Results posted
- No results posted in this snapshot
- Countries
- France
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Women and men * Aged 18-50 years (included) * Consulting their general practitioner * With chronic and diffuse musculoskeletal pain, without known etiology, lasting for at least 3 months * With a 25(OH)vitamin D deficiency \<20.8 ng/ml (52 nmol/l) at inclusion * Who signed the consent form Exclusion Criteria: * Identifiable source of pain requiring an appropriate specific management * Disease or treatment that may interfere with the metabolism of vitamin D * Current or previous hypercalcemia or hypercalciuria, treatment with digitalics and patients with history of nephrolithiasis * Current treatment with vitamin D or at least one vitamin D vial taken over the previous 6 months * Pregnancy or breastfeeding * not affiliated to a social security system * Refusal or inability to give consent
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT02002000