CORAL XT - Open-label Extension Trial of the CORAL Trial

Inclusion Criteria: * Informed consent signed indicating that the participant understands the purpose of and procedures required for the trial and is willing to participate in the trial. * Participants must be at least 18 years of age at the Enrollment Visit. * Women of childbearing potential must have a negative pregnancy test at enrollment and must not be lactating at the Enrollment Visit. * Participants must be willing to use medically acceptable and highly effective methods of birth control. * Participants who have completed treatment in KF6005/07 and are still in need of around-the-clock pain analgesia with strong opioids. Exclusion Criteria: * The participant has a clinically significant disease or condition other than cancer which in the investigator's opinion may affect efficacy or safety assessments. * Known to or suspected of not being able to comply with the protocol and the use of cebranopadol. * Participants taking forbidden concomitant medications or not being able to follow the rules of use of concomitant treatment. * History of torsade de pointes and/or presence of risk factors for torsade de pointes (e.g., heart failure, hypokalemia, bradycardia). * Concurrent participation in another trial (except participation in KF6005/07) or planning to be enrolled in another clinical trial (i.e., administration of experimental treatment in another clinical trial) during the course of this trial, or previous participation in this trial. * Employees of the sponsor, investigator, or trial site or family members of the employees, sponsor, or investigator.