A Retrospective Study to Identify New "Omics" Biomarkers of Chronic/Persistent Low Back Pain
CompletedNCT02037789
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Low back pain (LBP) is one of the most common medical problems encountered in daily life; it is related to disability and work absence and accounts for high economical costs in Western societies. Low-back pain is a diverse group of mixed pain syndromes (neuropathic and nociceptive) with different molecular pathologies at different structural levels displaying similar clinical manifestations. Currently, there are limited biomarkers (mostly imaging) or clinical findings that can be used objectively to help the physician in precise anatomic diagnosis leading to the safest and most cost-effective treatment for the patient (reduction of direct and indirect costs and improvement of treatment efficacy). The main aim of this trial is to identify all "omics biomarkers" associated with susceptibility to chronic/persistent LBP and its different pathophysiology.
Study details
- Official title
- A Retrospective Study to Identify New "Omics" Biomarkers of Chronic/Persistent Low Back Pain
- Conditions
- Persistent/Chronic Low Back Pain
- Sponsor
- University of Parma
- Collaborators
- GENOS; Ip Research Consulting Sasu; Helmholtz Zentrum München; YURII AULCHENKO; King's College London
- Start date
- 2014-03
- Primary completion
- 2016-02
- Sex
- All
- Age range
- from 18 Years to 99 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- Australia, Belgium, Croatia, Italy, United States
- Total sites listed
- 6
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria of patients with persistent CLBP: * age: older than 18; * chronic/persistent pain (pain lasting longer than 12 weeks) between the costal margins and gluteal fold, with or without symptoms into one or both legs * written informed consent signed; * Caucasian ancestry Inclusion Criteria of healthy volunteers: * age: older than 18; * without any chronic/persistent pain (pain lasting longer than 12 weeks) in the last one year; * written informed consent signed; * Caucasian ancestry Exclusion Criteria: * evidence of clinically unstable disease; * severe psychiatric disorder (excluding mild depression) or mental impairment; * recent history ( \< 1 year) of spinal fracture; * pain in the back due to spinal tumor or infection; * pregnancy
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT02037789