Analysis of Chronic Neuropathic Pain Markers in Patients Treated With Oxaliplatin
CompletedNot applicableNCT02169908
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The role of oxidative stress in the development of oxaliplatin-induced peripheral neuropathy has been previously described in mice and in neuronal cell cultures (Massicot 2013); clinical manifestations and pathophysiological mechanisms potentially involved have also been described in humans (Andreas 2007) (Attal 2009). The investigators team plans to conduct a translational clinicobiological research to explain the nature of the biochemical and molecular mechanisms of the development of oxaliplatin-induced painful neuropathy. To perform this project, the investigators propose to realize a pilot study in patients newly treated with oxaliplatin. This will be conducted in the oncology department of Paris Saint Joseph Hospital from May 2014 until the inclusion of 20 patients. The main objective of this pilot study is to evaluate the occurrence of acute and chronic neuropathic pain occurring in patients newly treated with oxaliplatin. The characterization of this pain is based on validated tests (Cruccu 2010). Moreover, the biochemical changes related to oxidative stress and those related to cellular lipid composition are characterized in these patients.
Study details
- Official title
- LIPIDOXA, a Pilot Study of Analysis of Chronic Neuropathic Pain Markers in Patients Treated With Oxaliplatin-based Regimen
- Conditions
- Digestive Cancer
- Gynecological Cancer
- Interventions
- Device: Thermotest
- Device: von Frey hairs
- Sponsor
- Fondation Hôpital Saint-Joseph
- Start date
- 2014-05
- Primary completion
- 2015-06
- Sex
- All
- Age range
- from 18 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- France
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Patient newly traeted with oxaliplatin * Patient suffering from any type of cancer treated with oxaliplatin * Man or Woman over 18 Exclusion Criteria: * Patient with brain or leptomeningeal metastases * Patient previously treated with cisplatin * Patient addicted to alcohol * Diabetic patient with peripheral neurological disorders * Patient receiving calcium or magnesium salts intravenously * Patient suffering from peripheral neuropathy * Patient suffering from psychiatric disorders * Patient treated with at least one of the following drug: venlafaxine, carbamazepine, gabapentin, pregabalin, clomipramine, amitriptyline, imipramine, duloxetine.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT02169908