Motor Threshold and Motor Cortex Stimulation
CompletedNot applicableNCT02255643
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Brief summary (from the registry)
Motor cortex stimulation (MCS) is a form of brain stimulation for patients with neuropathic pain not responsive to medication. An electrode is placed on the surface of the brain and connected to a programmable battery in the chest. The strength of stimulation can be individually adjusted by changing the voltage of stimulation. A too high voltage will produce side effects (e.g. seizures) while a too low voltage will not provide pain control. The aim of this study is to analyze the optimal stimulation parameters in patients already implanted with a motor cortex stimulation who have received good pain relief. The actual voltage may vary widely between patients but the investigators feel that there may be an "ideal" voltage if it is measured as a percentage of motor threshold (PMT). If motor threshold is the stimulation voltage that can evoke a muscle contraction then a PMT = 80% would be a voltage that was eighty percent of that value. Although the actual voltage may be widely different between patients, the percentage needed may be very similar. The investigators therefore plan to measure the effect of different percentages of PMT in patients already being treated with motor cortex stimulation. Systematic analysis of the findings of this study might help the individual participant and future patients to better programming and less side effects.
Study details
- Official title
- The Relationship Between Motor Threshold and Effective Stimulation Threshold During Motor Cortex Stimulation
- Conditions
- Interventions
- Device: Change of PMT setting
- Sponsor
- University of British Columbia
- Start date
- 2014-10
- Primary completion
- 2014-11
- Sex
- All
- Age range
- from 18 Years
- Results posted
- No results posted in this snapshot
- Countries
- Canada
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Adult patient more than 18 years of age * Chronic neuropathic pain effectively treated with motor cortex stimulation * Stable medication during the trial * Willing and able to comply with the study protocol and to return per the follow-up visit schedule and able to provide informed consent. Exclusion Criteria: * Evidence of an active disruptive psychiatric disorder or other known condition significant enough to impact the perception of pain, compliance to intervention and/or ability to evaluate treatment outcome as determined by the investigator * Technical malfunction of the MCS device * History of seizures * Unable to provide informed consent
Canadian sites (1)
| Facility | City | Province |
|---|---|---|
| Vancouver General Hospital | Vancouver | British Columbia |
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT02255643