The Immune and Endocrine Systems in Chronic Non-cancer Patients Treated With Opioids
CompletedNCT02277080
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The primary aim is to investigate the dose and time dependent effects of different opioids on the immune and endocrine systems. The secondary aim is to investigate whether associations between the function of the immune and endocrine systems and opioid use influence cognitive function, pain and quality of life.
Study details
- Official title
- The Immune and Endocrine Systems in Chronic Non-cancer Patients Treated With Opioids: Effects on Cognition, Pain and Quality of Life
- Conditions
- Pain
- Opioids
- Immune System
- Endocrine System
- Quality of Life
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
- Start date
- 2014-09
- Primary completion
- 2021-06
- Sex
- All
- Age range
- from 18 Years to 65 Years
- Results posted
- No results posted in this snapshot
- Total sites listed
- 0
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
CRITERIA FOR INCLUSION IN THE OPIOID GROUP * Age \>18 yrs and \<65 yrs * Chronic non-cancer pain (\>6 months' duration) * At least six years of schooling * Fluent in spoken and written Danish * On opioid treatment (\>30 mg of morphine equivalents pr. day) for at least one month CRITERIA FOR INCLUSION IN THE CONTROL GROUP * Age \>18 yrs and \<65 yrs * Chronic non-cancer pain (\>6 months' duration) * At least six years of schooling * Fluent in spoken and written Danish (no need for translator) * No analgesic treatment for the last month CRITERIA FOR EXCLUSION * Treatment with glucocorticoid or sex hormones within the previous 6 months or on-going therapy with drugs known to interfere with endocrine function * Treatment with adjuvant analgesics (anticonvulsants, antidepressants and others), NSAIDs/paracetamol, benzodiazepines and hypnotics (sleeping pills can be discontinued 3 days before testing) the last month * Known endocrine disease including insulin treated diabetes mellitus * Previously diagnosed dementia or encephalopathy * Brain trauma necessitating hospitalization within last 6 months * Previously diagnosed liver disease * Renal insufficiency (serum creatinine concentration \>140 µmol/l) * Pregnancy
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT02277080