Treating Urological Chronic Pelvic Pain Syndrome (UCPPS) Pain

Inclusion Criteria: * Males greater than 18 years of age, with no racial/ethnic restrictions; * Meets diagnostic criteria for Interstitial Cystitis with Painful Bladder Syndrome (IC/PBS) and/or Chronic Prostatitis with Chronic Pelvic Pain Syndrome (CP/CPPS); * Reports symptoms of discomfort or pain in the pelvic or abdominal region for at least a 3 mo period within the last 6 mo; * Must have a Visual Analog Scale (VAS) pain score \>40 mm (of 100 mm maximum) at the baseline visit (UCPPS pain moderate to severe); * Must be in generally stable health; * Must be willing to abstain from drinking alcohol during the course of the study; * Must be able to read and speak English and be willing to read and understand instructions as well as questionnaires; * Must sign an informed consent document after a complete explanation of the study documenting that they understand the purpose of the study, procedures to be undertaken, possible benefits, potential risks, and are willing to participate. Exclusion Criteria: * Urological pain associated with any systemic signs or symptoms, e.g., fever, chills; * Evidence of a facultative Gram negative or enterococcus with a value of ≥ 100,000 CFU/ml in mid-stream urine (VB2); * Has a second chronic pain condition (e.g., chronic low back pain, temporomandibular joint syndrome, etc.) that would prevent a clear interpretation of the study results; * History of tuberculous cystitis, bladder cancer, carcinoma in situ, prostate cancer, or urethral cancer; * History of significant pelvic comorbidities, including inflammatory bowel disease (such as Crohn's disease or ulcerative colitis), has undergone pelvic radiation, systemic chemotherapy, or intravesical chemotherapy, or has been treated with intravesical Bacillus Calmette-Guerin (BCG) or unilateral orchialgia without other pelvic symptoms, has an active urethral stricture, ureteral calculi, urethral diverticulum, or has a neurological disease or disorder affecting the bladder; * Significant other medical conditions/diseases, such as significant renal disease or a history of renal insufficiency, unstable diabetes mellitus, congestive heart failure, coronary or peripheral vascular disease, chronic obstructive lung disease, or malignancy; * Neurologic disorder, including history of seizures; * Major psychiatric disorder during the past 6 months; * Moderate or severe depression, as determined by the Hospital Anxiety and Depression Scale, or any active suicidal ideation; * History of, or c…