NEPAL (Neuromodulatory Examination of Pain and Mobility Across the Lifespan)

Brief summary (from the registry)

Musculoskeletal pain represents the leading cause of disability worldwide. It has been traditionally attributed to peripheral mechanisms, but peripheral damage, inflammation, and psychological factors have failed to significantly account for the presence, absence, or severity of chronic musculoskeletal pain (CMP). Recent studies show that individuals with CMP exhibit dysfunctional pain modulation supporting a significant central nervous system (CNS) contribution. However, the CNS mechanisms underlying these changes in pain modulation are not currently known, nor is their relation to clinical pain progression. The proposed pilot examines brain circuits recently described in predicting the transition from acute to chronic pain, in predicting clinical and experimental pain changes as well as physical performance and mobility changes in older persons with musculoskeletal pain over a one year period. The findings will provide novel and important information regarding the mechanisms underlying aberrant pain processing and its functional consequences in older adults with musculoskeletal pain. The information learned can be subsequently used to target treatment and prevention strategies in future studies of older adults. The central hypothesis is that increased functional and structural connectivity of cortico-striatal regions will be significantly associated with baseline clinical and experimental pain and decreased physical function in persons with CMP and will account for more rapid clinical pain and disability progression over time.

Study details

Official title

Neuroimaging Age-related Versus Pain-related Changes in Pain Modulation

Conditions

• Musculoskeletal Pain
• Pain, Chronic

Interventions

• Other: MRI Neuroimaging
• Other: Quantitative Sensory Testing
• Other: Questionnaires
• Other: Physical and Cognitive Function Testing

Sponsor

University of Florida

Collaborators

National Institute on Aging (NIA); National Institutes of Health (NIH)

Start date

2015-07

Primary completion

2024-02-04

Sex

All

Age range

from 18 Years

Healthy volunteers

true

Results posted

Yes, on ClinicalTrials.gov

Countries

United States

Total sites listed

4

Eligibility criteria