Multimodal Assessment of Sensory Processing and Brain Features in Patients With Chronic Orofacial Pain
CompletedNCT02630771
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
This proposal will investigate pain modulatory mechanisms and brain functional and structural characteristics using multiple MRI modalities in persistent dentoalveolar pain disorder (PDAP) patients with and without temporomandibular disorders (TMD). All measures from patients will be compared to painfree controls.
Study details
- Official title
- Multimodal Assessment of Sensory Processing and Brain Features in Patients With Chronic Orofacial Pain
- Conditions
- Toothache
- Temporomandibular Joint Disorders
- Interventions
- Procedure: Pressure pain threshold
- Sponsor
- University of Minnesota
- Start date
- 2016-01
- Primary completion
- 2019-03
- Sex
- Female
- Age range
- from 18 Years to 65 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- United States
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: 1. Age- and handedness-matched painfree controls using frequency matching to maintain similar group averages: * No self-report of persistent pain conditions for the last 6 months; * No diagnosis of PDAP or TMD; 2. PDAP only: * Fulfilling diagnostic criteria per Nixdorf et al., 20122 * Characteristic dentoalveolar PDAP pain cannot be increased by pressure provocation from jaw muscle trigger points (referred pain) 3. PDAP with TMD: * Fulfilling diagnostic criteria for PDAP2 and chronic TMD myalgia per Schiffman et al. 20143 Exclusion Criteria: Self-report: 1. Chronic widespread pain 2. Current use of opioids or other pain medications (e.g., ibuprofen/acetaminophen) that cannot be stopped \<3 days prior to testing 3. Conditions/diseases associated with altered pain perception: neurological (e.g., multiple sclerosis, trigeminal neuralgia) psychiatric disorders, diabetes, neoplasm and cardiovascular disorders 4. Injury to hands 5. Substance abuse 6. MRI contraindications including pregnancy
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT02630771