Pain In Neuropathy Study

Inclusion Criteria: * Patients who are ≥18 years of age who have a diagnosis of peripheral neuropathy based on a prior clinical assessment combined with supportive clinical investigations such as abnormal nerve conduction studies, reduced intraepidermal nerve or abnormal findings on quantitative sensory testing. * If supportive clinical investigations (as described above) are not available at entry into the study a neuropathy disability scale ≥3 (Pham et al., 2000). * And patients with symptoms highly suggestive of neuropathy that in the judgement of the clinical researcher are suitable for the study even if they do not fulfill other inclusion criteria. * Patients who do not fulfill any of the exclusion criteria. Exclusion Criteria: * Subjects who are pregnant. * Subjects with insufficient command of English to obtain consent from or to complete the study questionnaires. * Subjects with insufficient mental capacity to obtain consent from or complete study questionnaires. * Subjects with concurrent severe psychological or psychiatric disorders. * Patients with moderate to severe pain form other causes that may confound assessment or reporting of pain (eg. spinal canal stenosis). * Patients with central nervous lesions, which may complicate somatosensory testing. * Who is in the opinion of the investigator unsuitable for participation in the study. * Skin biopsies will not be conducted on patients that are anticoagulated or who have any other contra-indication to skin biopsy (if patients decline a skin biopsy they will NOT be excluded from the study).