Cortical Plasticity After Motor Cortex Stimulation in Healthy Subject and Chronic Pain Patients
CompletedNot applicableNCT02849834
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The primary aim of this study is to evaluate the induction of sensory-motor cortex plasticity after motor cortex stimulation in healthy subjects, using laser-evoked nociceptive cortical potentials, and in chronic neuropathic pain patients using functional MRI. As a secondary goal, the project will analyse possible correlations between the magnitude of cortical plasticity and that of the pain-relieving effect. In healthy subjects, cortical plasticity is evaluated by the comparison of somatosensory cortical maps before and after two isolated sessions of 20 Hz and theta-burst rTMS, in a cross-over randomized study. Two sessions of 5 consecutive days of rTMS are proposed to the patients with a minimum of 4 weeks between the two sessions, defined by 20 Hz and theta-burst stimulation in a cross-over randomized order. Cortical plasticity of the motor cortex is evaluated via functional MRI (motor activation) performed before the first rTMS session and the last day of each session of rTMS.
Study details
- Official title
- Study of Sensory-motor Cortex Plasticity After Motor Cortex Stimulation in Healthy Subject and Chronic Pain Patients
- Conditions
- Sponsor
- Hospices Civils de Lyon
- Start date
- 2009-11
- Primary completion
- 2016-11-21
- Sex
- All
- Age range
- from 18 Years to 70 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- France
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * healthy subjects aged from 18 to 70 years, male or female, with social protection, fully informed and having given their written consent. * patients : * aged from 18 to 80 years, male or female, with social protection , fully informed and having given their written consent. * unilateral pharmacoresistant neuropathic pain during at least one year, * without any change of the pharmacological treatment since at least one month Exclusion Criteria: * for healthy subjects only: * history of chronic pain * analgesic medication within 24h before stimulation For patients only: new analgesic treatment within 1 month before consent for both: * drug addiction, headache, epilepsy history * ferromagnetic intracranial device * implanted stimulator * absence of contraceptive method for women of childbearing age
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT02849834