Trans-MAPP II Study of Urologic Chronic Pelvin Pain

Inclusion Criteria: * Participant has signed and dated the appropriate Informed Consent document. * Agreed to participate in ALL required study procedures (including Biospecimen collections, Neuroimaging, and Quantitative Sensory Testing). * Gave permission for use of DNA for genetics studies. * Gender recorded in Participant Registration module. * Participant is at least 18 years of age. * Participant is able to speak, read, and understand English. * Participant reports a response of "0" (zero) on the pain, pressure or discomfort scale (SYM-Q, Question #1). * Participant reports no chronic pain in the pelvic or bladder region, and reports no chronic pain in any other body region. * Participant reports no urological symptoms that have been evaluated, but are still present. Exclusion Criteria: * Participant has an on-going symptomatic urethral stricture. * Participant has an on-going neurological disease or disorder affecting the bladder or bowel fistula. * Participant has a history of cystitis caused by tuberculosis, radiation therapy or Cytoxan/cyclophosphamide therapy. * Participant has augmentation cystoplasty or cystectomy. * Participant has an active autoimmune or infectious disorder (such as Crohn's Disease or Ulcerative Colitis, Lupus, Rheumatoid Arthritis, Multiple Sclerosis, or HIV). * Participant has a history of cancer (with the exception of skin cancer). * Participant has current major psychiatric disorder or other psychiatric or medical issues that would interfere with study participation (e.g. dementia, psychosis, upcoming major surgery, etc.). * Participant has severe cardiac, pulmonary, renal, or hepatic disease that in the judgment of the study physician would preclude participation in this study. * Participant has had definitive treatment for acute epididymitis, urethritis, vaginitis. * Participant has history of unevaluated hematuria, this will require the evaluation of a study physician to determine if this has been appropriately evaluated. * Participant has had a cystoscopy with hydrodistention or kenalog injection. Exclusion Criteria for Males Only: * Diagnosis of unilateral orchalgia, without pelvic symptoms. * History of transurethral microwave thermotherapy (TUMT), transurethral needle ablation (TUNA), balloon dilation, prostate cryo-surgery, or laser procedure. * A prostate biopsy or transurethral resection of the prostate (TURP) within the last three months. Exclusion Criteria for Females Only: • Participant has a positive Urine …