Effects of Behavioral Interventions on Mechanisms of Pain Regulation and Hedonic Regulation
TerminatedNot applicableNCT02935465
View the official record on ClinicalTrials.gov Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.
This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The overarching aim of this project is to conduct a randomized controlled study to determine whether Mindfulness-Oriented Recovery Enhancement (MORE) vs. a Support Group (SG) can improve pain regulation and hedonic functions (i.e., natural reward responsiveness) thought to be governed by the endogenous opioid system among opioid-treated, chronic, non-neuropathic back pain patients (CNBP) and thereby improve clinical pain, affect, and opioid use.
Study details
- Official title
- Effects of Behavioral Interventions on Mechanisms of Pain Regulation and Hedonic Regulation in Opioid-Treated Chronic Pain Patients
- Conditions
- Chronic, Non-neuropathic Back Pain
- Interventions
- Behavioral: Mindfulness-Oriented Recovery Enhancement (MORE)
- Behavioral: Support Group
- Sponsor
- University of Utah
- Collaborators
- National Center for Complementary and Integrative Health (NCCIH)
- Start date
- 2016-09
- Primary completion
- 2019-06
- Sex
- All
- Age range
- from 21 Years to 60 Years
- Results posted
- No results posted in this snapshot
- Countries
- United States
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: 1. age 21-60 years of age 2. English fluency 3. 20/20 vision with corrective lenses 4. current chronic, non-neuropathic back pain diagnosis determined by physician assessment 5. reporting pain ≥3 on 0-10 scale with opioid medication 6. current use of prescription opioids for ≥3 consecutive months 7. ability to understand study procedures and to comply with them for the entire length of the study Exclusion Criteria: 1. Mindfulness experience (e.g., MBSR or shamatha/vipassana meditation) 2. psychosis 3. untreated, active suicidality in the past month 4. and severe non-opioid substance use disorder in the past year as assessed with the MINI 5. clinically unstable illness judged to interfere with treatment, and presence of facial/jaw pain 6. pregnancy 7. inability or unwillingness of individual to give written informed consent 8. physical characteristics that preclude neuroimaging or study procedures (e.g., metal implants, etc.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT02935465