Analgesic Effect of Non Invasive Stimulation : Transcranial Direct Current Stimulation of Opercular-insular Cortex
CompletedNot applicableNCT03015558
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The aim of this study is to evaluate, versus placebo, the analgesic efficacy of the opercular-insular cortex stimulation with Transcranial Direct Current Stimulation (tDCS), in both healthy subjects and chronic neuropathic pain patients. In healthy subjects analgesia by tDCS will be assessed using both laser stimuli and cold pressor test. In patients the assessment regards their chronic pain (ratings for ongoing, evoked and paroxysmal pain, sleep and fatigue). Opercular-insular stimulation is obtained via a combined 6-electrode montage and by bi-vestibular stimulation (since vestibular pathways reach the posterior insular cortex). In patients, three separate conditions (two active and one sham) will be tested in randomised order. In healthy subjects, two other conditions are added to control for attention and distraction confounders.
Study details
- Official title
- Transcranial Direct Current Stimulation (tDCS) for Neuropathic Chronic Pain : Study of the Opercular-insular Cortex Stimulation
- Conditions
- Interventions
- Device: transcranial direct current stimulation of opercular-insular cortex - anodal active tDCS session
- Device: transcranial direct current stimulation of opercular-insular cortex - active control session
- Device: transcranial direct current stimulation of opercular-insular cortex - sham control session.
- Sponsor
- Hospices Civils de Lyon
- Start date
- 2016-11-02
- Primary completion
- 2018-03-28
- Sex
- All
- Age range
- from 18 Years to 80 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- France
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * healthy subjects aged from 18 to 70 years, male or female, with social security protection, fully informed and having given their written consent. * patients aged from 18 to 80 years, male or female, with social security protection , fully informed and having given their written consent. * pharmacoresistant neuropathic pain during at least one year, * without any change of the pharmacological treatment since at least one month Exclusion Criteria: In healthy subjects only: * history of chronic pain * analgesic medication within 24h before stimulation For patients only: new analgesic treatment within 1 month before consent for both: * drug addiction, headache, epilepsy * ferromagnetic intracranial device * implanted stimulator * recent neurosurgery and open wound of the scalp. * absence of contraceptive method for women of childbearing age
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT03015558