Evaluating the Role of Neuroinflammation in Low Back Pain
CompletedPhase 2NCT03106740
View the official record on ClinicalTrials.gov Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.
This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
In this research, the study team will use brain imaging to evaluate the presence of neuroinflammation in the brains and spinal cords of patients with low back pain. The efficacy of minocycline use for low back pain treatment will also be evaluated by observing whether short-term minocycline administration will reduce neuroinflammation and low back pain symptoms.
Study details
- Official title
- Imaging Glia-mediated NeuroInflammation and Treatment Efficacy (the IGNITE Study)
- Conditions
- Low Back Pain
- Back Pain With Radiation
- Back Pain Without Radiation
- Back Pain Lower Back Chronic
- Back Ache
- Pain, Chronic
- Interventions
- Drug: Minocycline Hydrochloride 100mg Capsule
- Diagnostic test: Magnetic Resonance-Positron Emission Tomography Imaging
- Other: Placebo Capsule
- Sponsor
- Marco Loggia
- Collaborators
- National Institute of Neurological Disorders and Stroke (NINDS)
- Organization
- Massachusetts General Hospital
- Start date
- 2017-10-10
- Primary completion
- 2024-04-30
- Sex
- All
- Age range
- from 18 Years to 75 Years
- Results posted
- Yes, on ClinicalTrials.gov
- Countries
- United States
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * the ability to give written informed consent * fluency in English * on a stable pain treatment * Chronic or sub-acute low back pain Exclusion Criteria: * no interventional pain procedures during drug trial * contraindications to MRI and PET scanning (including presence of a cardiac pacemaker or pacemaker wires, metallic particles in the body, vascular clips in the head or previous neurosurgery, prosthetic heart valves, claustrophobia) * pregnancy or breast feeding * any use of recreational drugs in the past 6 months * allergy to minocycline or other tetracyclines, or taking medications known to interact with minocycline * any other contraindications to minocycline administration
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT03106740