Hyperbaric Oxygen Therapy for Inflammatory Conditions of the Urinary Bladder

Inclusion Criteria: * CIC/PBS- patients with urinary tract pain or discomfort and dysuria that is present for \> 6 months and is not due to acute urinary tract infection, stones or other urinary pathology. * rUTI- patients with greater that 2 urinary tract infections in 6 months or greater than 3 urinary tract infections in one year. A UTI is defined as - symptomatic complaints of dysuria, increased frequency of urination, and hesitancy to urinate and a clean catch urinary culture with \>103 colony counts of bacteria per milliliter. Exclusion Criteria: * Inability to provide written informed consent * Inability or unwillingness to adhere to 40 HBOT treatment sessions over an 8-10 week time period or to complete follow up questionnaires/telephone contacts. * Confinement anxiety and inability to enter the hyperbaric chamber for a 90 minutes treatment session. * Inability to effectively equalize the middle ear during changes in ambient pressure. This will include patients with a history of tympanic membrane perforation, head and neck surgery with compromised Eustachian tube function, including but not limited to tracheostomy, mastoidectomy, middle ear surgical procedures and cochlear implants. * Presence of an indwelling urinary catheter * Any acute or chronic urinary condition that is not rUTI or CIC/PBS- such as but not limited to urinary bladder stones, tumors, urinary retention, adynamic urinary bladder, chemotherapy related hemorrhagic cystitis, radiation cystitis or other pathology. * Active or uncontrolled cancer diagnosis. * Active or uncontrolled psychiatric disease. * American Heart Association Class III or greater congestive heart failure or symptomatic coronary artery disease. * Active or uncontrolled pulmonary diseases- including asthma, COPD, bullous lung disease, previous thoracotomy, pneumothorax or history of pneumothorax. * Acute upper respiratory tract infection. * End stage renal disease receiving hemo- or peritoneal dialysis * Active or history of seizure disorder * Hemolytic blood dyscrasias * History of exposure to bleomycin * Presence of a pacemaker or epidural pain pump * Pregnant or lactating women * Patients with type 2 diabetes * Patients with neurovascular diseases (e.g. recent stroke) * Patients with uncontrolled hypertension * Patients with retinitis pigmentosa * Patients taking the following concomitant medications: PDE5 inhibitors, carbonic anhydrase inhibitors, beta blockers, alpha blockers, nitrates.