PET Imaging of Chronic Pain Syndromes

Inclusion Criteria for Chronic Pain Patients: * Age greater than 18 years old. * Have chronic pain symptoms for \>3 months; * Have moderate pain (\>3/10) in 2 or more areas for more than 5 out of 7 days * Is planning on undergoing chiropractic care for the clinical management of the chronic pain. * May be on pain medications provided that they are on a stable dose for at least 1 month * Patients have no other pre-existing and active significant medical, neurological, or psychological disorders. * Minor, stable health problems that should have no substantial effect on cerebral blood flow will be allowed (i.e. controlled hypertension, medication controlled diabetes). * Patients will be allowed to be taking medications or supplements at the initial intake, but they must be on a stable dose regimen for at least 1 month. * Able to give informed consent and willing to complete the study at Thomas Jefferson University and Marcus Institute of Integrative Health. Inclusion Criteria for Healthy Controls: * No significant current active medical conditions. * Stable medical conditions as determined by the PI are allowed. * No brain or body abnormalities that would affect the acquisition or analysis of the scan. Exclusion Criteria for Chronic Pain Patients and Healthy Controls: * Pregnant or breast feeding * Enrollment in active clinical trial/ experimental therapy within the prior 30 days. * Subject is unable or unwilling to lie still in the scanner (i.e. due to claustrophobia or weight) * Subject has metal in their body or other reason that they cannot undergo magnetic resonance imaging.