Safety and Efficacy of Medical Cannabis Oil in the Treatment of Patients with Chronic Pain

Inclusion Criteria: 1. Written informed consent 2. Adult patients (older than 18 years of age), male and female, with chronic non-cancer and cancer pain (at least 3 months in duration) 3. Patients experiencing an average weekly pain intensity score greater than 4 on a 11 points NRS 4. Subject agreed to follow the protocol 5. Naïve cannabis patients with chronic non-cancer and cancer pain (not used cannabis in any presentation in the last 12 weeks) 6. Patients receiving opioids and other concomitant pain medications should have a stable dose for the last 15 days. 7. Normal cognitive status according to MiniCog 8. Normal liver function (defined as aspartate aminotransferase 10-40 U/L and alanine aminotransferase 7-56 U/L) 9. Normal renal function (defined as serum creatinine level \<133 µmol/L and Estimated Glomerular Filtration Rate (eGFR) greater than or equal to 60) 10. Negative result on βhuman chorionic gonadotropin pregnancy test (if applicable) 11. Ability to read and respond to questions in French or English. 12. A female volunteer must meet one of the following criteria: If of childbearing potential - agrees to use one of the accepted contraceptive regimens from at least 28 days prior to the first drug administration, during the study and for at least 60 days after the last dose. If of non-childbearing potential - should be surgically sterile or in a menopausal state 13. A male volunteer with sexual partners who are pregnant, possibly pregnant, or who could become pregnant must be surgically sterile or agrees to use one of the accepted contraceptive regimens from first drug administration until 3 months after the last drug administration. Exclusion Criteria: 1. Acute pain (less than 3 months in duration) 2. Previous serious adverse event or hypersensitivity to cannabis or cannabinoids 3. Inability to understand and comply with the instructions of the study 4. Presence of significant cardiac disease (history of unstable ischemic heart disease, heart failure, severe and uncontrolled hypertension) that, in the opinion of the investigator, would put the patient at risk of a clinically significant arrhythmia or myocardial infarction 5. Current substance use disorder according to the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM 5) 6. Life-time history of dependence on cannabis or diagnosis of cannabis use disorder (CUD) according to the DSM 5 7. Life-time history of DSM 5 schizophrenia, bipolar disorder, or previous psychosis w…