Intrathecal Morphine Microdose Method Sensory Changes
WithdrawnNot applicableNCT03395275
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Following the retrospective study on the effectiveness of the microdose method of intrathecal morphine therapy, the investigators are interested in measuring the sensory changes at 4 time points during the microdose method. The microdose method involves weaning the patient off oral opioids and maintaining an opioid-free period prior to initiating a very low opioid dose in intrathecal therapy. The microdose method is a standard of care. The study involves measuring sensory changes to hot, cold, and pressure. Data collection will be performed at regularly scheduled clinic visits, examining range of doses, pain scores,dose escalations, quantifiable psychosocial factors ( not captured in previous retrospective study), and changes in sensory thresholds.
Study details
- Official title
- Intrathecal Morphine Microdose Method Sensory Changes: A Pilot Study
- Conditions
- Analgesic Drug Dependence
- Sensory Disorders
- Chronic Pain
- Interventions
- Behavioral: Quantitative Sensory Tests
- Behavioral: surveys
- Sponsor
- The University of Texas Medical Branch, Galveston
- Start date
- 2018-10-08
- Primary completion
- 2023-02-03
- Sex
- All
- Age range
- from 18 Years to 75 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Total sites listed
- 0
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Age between 18 and 75 * Selected for microdose Intrathecal pump therapy by their pain physician * Chronic pain for at least 3 months * Willing to cooperate with all study procedures Exclusion Criteria: * Presence of cancer * Age less than 18 years old or greater than 75 * Current intrathecal therapy and/or with multiple intrathecal drugs (such as other opioids, local anesthetics, muscle relaxants) * Medical conditions (myocardial infarction within the last year, uncontrolled diabetes, autoimmune disease * Recent history of alcohol or substance abuse in the last 5 years
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT03395275