Comparison of Oral Lamotrigine Versus Pregabalin for Control of Acute and Chronic Pain
AvailableNCT03419949
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Breast cancer is the most frequent neoplastic tumor in women, and surgical treatment is indicated in most patients. Complications related to this treatment, such as post-mastectomy pain syndrome (PMPS), a persistent pain that develops after surgery, have been reported. Although the genesis of the pain is multifactorial, sectioning of the intercostobrachial nerve is the nerve lesion diagnosed more often (1) .. Pain relief using drugs with high efficacy provides significant improvement in the patients' lives. Drugs like lamotrigine (LTG) and gabapentin (GBP) have the ability to overcome the symptoms of neuropathic pain (4). Both LTG and PGB have been extensively reviewed in the past for management of painful neuropathic conditions (5)
Study details
- Official title
- Comparison of Oral Lamotrigine Versus Pregabalin for Control of Acute and Chronic Pain Following Modified Radical Mastectomy: Controlled Double-blind Study
- Conditions
- Acute and Chronic Pain Following Modified Radical Mastectomy
- Interventions
- Drug: oral lamotrigine 100 mg
- Drug: oral pregabalin 150 mg
- Sponsor
- Assiut University
- Sex
- Female
- Age range
- from 18 Years to 60 Years
- Results posted
- No results posted in this snapshot
- Countries
- Egypt
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * female patients with ASA I-II, aged 18-60 years, have BMI \< 30 km\\ m2 and scheduled for modified radical mastectomy with axillary dissection for management of breast cancer Exclusion Criteria: \- Excluded from the study are patients with known allergy to the study drugs, significant cardiac, respiratory , renal, CNS or hepatic disease, drug or alcohol abuse, pregnant women, patients refusing participation and psychiatric or mental illness that would interfere with perception and assessment of pain
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT03419949