Management of Ischemic Heart Disease With Angiwell-XR (Ranolazine)

Inclusion Criteria: * Patients with diagnosis of coronary artery disease (CAD) * Patients present with the symptoms of stable angina after withdrawn from other antianginal drugs and given the required background therapy for at least 7 days will be qualified for entering this study and performing 1st ETT qualifying test * Patients developed exercise-induced ECG ischemiai during two qualifying exercise treadmill testsii. * Willing and able to provide a written informed consent Exclusion Criteria: * • Factors that might compromise ECG or ETT interpretation * Patients with resting ST-segment depression ≥ 1mm in any lead * Left bundle-branch block * Patients implanted with pacemaker * Patients under Digitalis therapy * Patients with family history of (or congenital) long QT syndrome * Patients with congenital heart disease * Patients with uncorrected valvular heart disease * Patients with unstable angina, or MI, or coronary revascularization procedure ≤ 2 months prior enter this study * Female who is pregnant/lactating or planning to be pregnant, or female of childbearing potential\* who is not using medically recognized method of contraception * \*Other than those who have been surgically sterilized (defined as having undergone hysterectomy or bilateral oophorectomy or bilateral salpingectomy; tubal ligation alone is not considered sufficient) or one year post-menopausal. • Patients are under any one of the following conditions: * New York Heart Association (NYHA) Class III or Class IV congestive heart failure (CHF) * QTc \> 450 msec at screening * Active myocarditis, pericarditis, hypertrophic cardiomyopathy * Uncontrolled hypertension (defined as SBP \> 180 mmHg) Voltage criteria for left ventricular hypertrophy in the absence of repolarization abnormalities will not be exclusion criteria * Use of any investigational product ≤ 4 weeks prior to screening * Patients with severe hepatic disease (e.g., liver cirrhosis) * Patients with impaired renal function (defined as serum Cr \>1.5 mg/dl) * Patients with any condition or disease which is considered not suitable for this study by investigator