Pain Research: Innovative Strategies With Marijuana
CompletedNCT03522324
View the official record on ClinicalTrials.gov Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.
This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
This study tests the effects of cannabinoid levels in blood on pain relief, inflammation, and cognitive dysfunction in chronic pain patients who choose to use edible cannabis. Over a two-week period, participants use an edible product of their choice. Blood levels of 9-delta-tetrahydrocannabinol (THC) and cannabidiol (CBD) will be measured before, during, and after the two-week exposure period to determine whether there are associations with pain, inflammation, sleep, physical activity, anxiety/depression, and cognitive dysfunction. After the two-week self-administration period, participants will be followed for six months to collect self-report data on cannabis use, pain levels, sleep quality, and mental health symptoms.
Study details
- Official title
- An Observational Study of the Effects of Edible Cannabis and Its Constituent Cannabinoids on Pain, Inflammation, and Cognition
- Conditions
- Chronic Pain
- Chronic Low Back Pain
- Cannabis Use
- Interventions
- Drug: Cannabis Edible
- Sponsor
- University of Colorado, Boulder
- Collaborators
- University of Colorado, Denver; Colorado State University
- Start date
- 2018-06-01
- Primary completion
- 2023-04-10
- Sex
- All
- Age range
- from 21 Years to 70 Years
- Results posted
- Yes, on ClinicalTrials.gov
- Countries
- United States
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Intent to initiate use of marijuana to treat chronic pain * At least one episode of lifetime marijuana use, but infrequent marijuana use for prior six months * Self-reported non-specific chronic low back pain for at least three months * Health eligibility approved by study physician * At least mild to moderate pain intensity OR pain interferes with important life functions Exclusion Criteria: * Other drug use (cocaine, methamphetamine, etc.) in the past 3 days and/or actively seeking or in treatment for any substance use disorder * Use of marijuana to treat pain at any time in lives * Current use of psychotropic medications (other than SSRIs and ADHD meds), or use of antivirals, steroids, or regular use of maximal doses of NSAIDS * A daily tobacco user * Are currently pregnant or trying to become pregnant * Acute illness (other than chronic pain) or any immune-related disease (e.g., HIV)
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT03522324