Skip to content

Physical Activity on Neurophysiologic Gene Expression Profiles of Chronic Low Back Pain

CompletedNot applicableNCT03637998
View the official record on ClinicalTrials.gov

Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.

This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.

Brief summary (from the registry)

This pilot project will provide an understanding of the contextual variables responsible for chronic low back pain. These variables include, genetic variation, pain sensitivity, reactivity, pain catastrophizing, perceived stress and kinesiphobia. The purpose is to understand the initial efficacy of self-management (SM) strategies on each of these contextual variables, in an effort to inform a personalized approach to managing chronic low back pain and its effect on improved health outcomes.

Study details

Official title
The Impact of Physical Activity on the Neurophysiologic and Gene Expression Profiles of Chronic Low Back Pain: A Longitudinal Study Protocol
Conditions
Interventions
  • Behavioral: Problem-solving Pain to Enhance Living Well (PROPEL)
Sponsor
University of Connecticut
Collaborators
National Institute of Nursing Research (NINR)
Start date
2018-09-21
Primary completion
2021-12-31
Sex
All
Age range
from 18 Years to 60 Years
Results posted
No results posted in this snapshot
Countries
United States
Total sites listed
1

Eligibility criteria

Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * be 18-60 years of age; * have nonspecific cLBP (≥4 on the numeric rating scale; NRS) present for at least 3 out of the last 6 months and ≥ half the days in the past 6 months; * comprehend English (due to lack of reliability and validity of study instruments and the intervention in non-English populations). * Have daily access to a computer, tablet or smartphone with access to internet * Have less than 150 minutes of moderate physical activity a week * Be willing to wear activity tracker for 12 weeks Exclusion Criteria: * Chronic pain at another site or associated with a painful condition (eg., fibromyalgia, neuropathy, rheumatoid arthritis) * history of comorbidities that affect sensorimotor function (eg., multiple sclerosis, cancer, spinal cord injury, diabetes) * previous spinal surgery within last 1 year * presence of neurological deficits such as weakness in the lower extremities (motor strength 4/5 of quads, glutes, hamstrings, EHL) * bowel or bladder dysfunction such as difficulty voiding or incontinence * sciatica or (+) leg raise * positive Romberg test * being pregnant or within 3 months postpartum * history of psychological disorders (major depression, bipolar disorder, schizophrenia) * identification of any "red flag" condition in the volunteer's past medical history that suggests specific LBP as determined by Dr. Kim such as conditions or medications that can affect pain sensitivity * injury to non-dominant hand or presence of open skin lesions, disturbed sensation, carpal tunnel or rash

Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT03637998