Human Behaviors Related to the Expectation of Pain
TerminatedNot applicableNCT03739645
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The conditioned expectation of pain is an important aspect of pain-related disability produced by environments and stimuli associated with a painful injury on the job, although the neuroscience of this expectation is unclear. We will develop and use novel objective methods for measurement of expectation and threat related attention. The results of this study may lead to testable hypotheses regarding the psychological basis of the fear of pain, threat and task related attention. We will also use these results, and development of novel autonomic and ratings metrics for state and trait anxiety as well as threat and task related attention which could be used as an instrumented test for diagnosis and management of PTSD and anxiety disorders. .
Study details
- Official title
- Physiological Studies in Healthy Subjects, Chronic Pain Patients and in Patients Undergoing Neurosurgical Procedures of Human Forebrain Mechanisms Mediating Somatic Sensation, Motor Control and Neurological Disorders
- Conditions
- Fear Pain
- Interventions
- Behavioral: Skin conductance levels and slopes over time in conditioned fear as metrics.as metrics for anxiety
- Sponsor
- Johns Hopkins University
- Collaborators
- University of Maryland; National Institute of Neurological Disorders and Stroke (NINDS)
- Start date
- 2020-08-01
- Primary completion
- 2023-10-01
- Sex
- All
- Age range
- from 16 Years to 88 Years
- Healthy volunteers
- true
- Results posted
- Yes, on ClinicalTrials.gov
- Countries
- United States
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Man or woman between 18 and 80 years of age. * Fluent speaker of English. * Undergoing seizure monitoring at Hopkins Hospital through intracranial electrodes. * Possess ability to understand study procedures and comply with them for the entire length of the study; * Women of childbearing age must use pharmacological contraception (oral or patch) for the duration of the study follow-up. Exclusion Criteria: * Inability or unwillingness of individual to give written informed consent. Presence of any neurological disease other than epilepsy which is unstable or is not optimally treated. * Presence of a significant abnormality on routine neuropsychological testing. * Presence of any medical or psychiatric disease which is unstable or is not optimally treated. Presence of an abnormal MRI scan except for Normal variants or Medial Temporal Sclerosis (altered pathology and MRI signal in temporal lobe). * Women who are pregnant or women of childbearing capacity who may become pregnant (i.e. not using contraception). * Presence of generalized seizures, or reflex seizures i.e. triggered by a sensory stimulus. * Presence of a language or hearing impairment. * Non-English speakers.
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT03739645