Effects of Exercise and Education in Patients With Chronic Pain After Total Knee Replacement
CompletedNot applicableNCT03886259
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The purpose of the study is to investigate whether a 12-week neuromuscular rehabilitation program (NEMEX-TJR) combined with pain neuroscience education (PNE) provides greater pain relief, improvement in physical function and quality of life than PNE alone in a population of patients with chronic pain after primary total knee arthroplasty. Hypothesis: Rehabilitation involving neuromuscular training and PNE will provide greater pain relief, improved function and improved quality of life compared to PNE alone at the primary endpoint, which is follow-up 12months after the start of the treatment.
Study details
- Official title
- Effect of Neuromuscular Exercise in Combination With Pain Neuroscience Education Compared to Pain Neuroscience Education Alone in Patients With Chronic Pain After Primary Total Knee Arthroplasty: A Randomized Controlled Trial
- Conditions
- Arthroplasty, Replacement, Knee
- Chronic Pain
- Interventions
- Other: Neuromuscular exercises (NEMEX-TJR) and pain neuroscience education
- Other: Pain neuroscience education
- Sponsor
- Aalborg University
- Collaborators
- Northern Orthopaedic Division, Denmark; The Danish Rheumatism Association; Svend Andersen Foundation; Lions Denmark
- Start date
- 2019-04-01
- Primary completion
- 2023-02-21
- Sex
- All
- Age range
- from 40 Years to 80 Years
- Results posted
- No results posted in this snapshot
- Countries
- Denmark
- Total sites listed
- 3
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * Body Mass Index (BMI) between 19-40 * Subjects with primary total knee arthroplasty due to osteoarthritis ≥ 12 months post-operatively * For the index knee, duration of knee pain \> 6 months * For the index knee, the average daily pain score ≥ 4 (moderate-to-severe pain) over the last week prior to visit on a numeric rating scale Exclusion Criteria: * Specific reasons for chronic pain, such as loosening of implant, which requires revision surgery * Secondary causes of arthritis to the knee, e.g. rheumatoid arthritis * Surgery (including arthroscopy) of the index knee within 3 months prior to visit * Injury to the index knee within 12 months prior to visit * Recent history of acute pain affecting the lower limb and/or trunk * Participation in other pain trials two weeks prior to this study * Pregnancy * Drug and alcohol abuse * Previous neurologic illnesses or primary pain area other than knee, e.g. lower back, upper extremity pain or rheumatoid arthritis * Lack of ability to adhere to protocol
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT03886259