Histological and Molecular Mechanisms of Pain in Patient With Chronic Pain From Adhesions
CompletedNCT03938168
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
11-20% of patients undergoing abdominal surgery develop chronic abdominal pain. Adhesions are a common cause of chronic pain following surgery. Adhesions develop after up to 90% of laparotomies and 70% of laparoscopic surgeries. Obviously, not all adhesions cause pain. It is still poorly understood why adhesions cause pain in some patients, while other patients with adhesions experience no pain. In this study we explore possible mechanism through which adhesions might cause pain. For this purpose we will assess expression of molecular mediators (such as TRPV-1, SP, and the neurokinin receptor), histological characteristics, and fecal microbioma that might be associated with pain.Expression of these factor will be compared to sample from 30 patients with chronic pain attributed to adhesions, and 30 patients undergoing a reoperation with adhsiolysis for reasons unrelated to pain.
Study details
- Official title
- PAIN PAD Histological and Molecular Mechanisms of Pain in Patient With Chronic Pain From Adhesions
- Conditions
- Tissue Adhesion
- Chronic Pain
- Surgery
- Interventions
- Diagnostic test: Biopsy, fecal sample
- Sponsor
- Radboud University Medical Center
- Collaborators
- Maastricht University Medical Center; Maas Hospital Pantein
- Start date
- 2019-04-09
- Primary completion
- 2023-12-31
- Sex
- All
- Age range
- from 18 Years
- Results posted
- No results posted in this snapshot
- Countries
- Netherlands
- Total sites listed
- 3
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
In order to be eligible to participate patients with chronic pain, must meet all of the following criteria: * Abdominal pain for more than 12 months after last surgery * Insufficient improvement of pain after conservative treatments for at least 6 months * Pre-operative work-up with cineMRI showing expected beneficial outcomes of adhesiolysis, in accordance to our current standard practice for adhesion-related pain. Inclusion criteria for controls: * Patients between 18 and 75 years old scheduled for elective abdominal reoperation * No present chronic abdominal pain * No other diseases or syndromes that cause chronic pain (e.g. rheumatic arthritis) Exclusion criteria A potential subject with chronic pain will be excluded from participation in this study in the following cases: * Contra-indications for general anaesthesia and re-operation * Inability to acquire informed consent
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT03938168