Extracorporeal Shock Wave Lithotripsy and Endotherapy for Pain in Chronic Pancreatitis

Inclusion Criteria: * Patients from the ages of 18 with a diagnosis of chronic calcific pancreatitis diagnosed using the Mayo Clinic diagnostic criteria. Both diabetic and non-diabetic patients will be allowed to enter the study. * The patients must suffer from chronic abdominal pain characteristic for CP with a pain intensity \>3 VAS on a 0-10 VAS and meet the criteria for chronic pain (pain ≥ 3 days per week in at least 3 months). * Obstruction of the pancreatic duct due to intraductal stones with dilatation of the duct proximal to the obstruction, as determined by magnetic resonance cholangiopancreatography, abdominal computed tomography, or both. * The patients must be able to read and understand the provided informed consent. * Patients must personally sign and date informed consent document indicating that he/she has been informed of all pertinent aspects of the trial. * Patients should be willing to comply with the scheduled visits, clinical and experimental assessment plan, and other trial procedures. Exclusion Criteria: * Patients with any clinically significant laboratory abnormalities that in the opinion of the investigator may increase the risk associated with trial participation or may interfere with the interpretation of the trial results. * Previous history of pancreatic surgery, ESWL or ERCP. * Patients with a pancreatic stricture on cross-sectional imaging prior to study enrolment * Active alcohol or illegal drug dependencies. * Patients with evidence or history of medical or surgical disease of importance for this study as judged by investigator. * Patients must not suffer from painful conditions other than CP that make them unable to distinguish the pain associated with CP from chronic pain of other origin. * Presence of pancreatic head mass, multiple strictures, large ascites, large fluid collections.