Identifying Biomarkers and Changes in Cerebrospinal Fluid Collected Pre and Post Spinal Cord Stimulation in Subjects Suffering From Chronic Refractory Pain Conditions
TerminatedNot applicableNCT03986255
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
This is a single center exploratory study in subjects suffering from chronic refractory pain to identify cellular, molecular and protein biomarkers within cerebrospinal fluid (CSF). The study aims to identify any form of correlation between biological content of CSF and pain/treatment success. The study population include individuals suffering from chronic pain which has not been effectively treated with pharmacological treatment, medical intervention or alternative non-invasive treatments who have been scheduled for spinal cord stimulation.
Study details
- Official title
- Identifying Biomarkers and Changes in Cerebrospinal Fluid Collected Pre and Post Spinal Cord Stimulation: A Single Centre, Prospective, Exploratory Study in Subjects Suffering From Chronic Refractory Pain Conditions
- Conditions
- Interventions
- Procedure: Lumbar Puncture
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
- Start date
- 2019-03-19
- Primary completion
- 2021-12-20
- Sex
- All
- Results posted
- No results posted in this snapshot
- Countries
- United Kingdom
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: 1. Be capable of understanding and signing a written consent form 2. Subjects suffering from chronic neuropathic pain which has not been effectively managed with pharmacotherapy, medical interventions or alternative non-invasive treatments 3. Pain VAS score ≥ 5 on more than 3 days a week at least over three months. 4. Subjects deemed a suitable candidate receive spinal cord stimulator device as determined by a pain management specialist 5. No known contraindication to spinal cord stimulation 6. Does not have an active systemic or local infection Exclusion Criteria: 1. Structural abnormalities of the spine at L2-L3 that may impact study procedure 2. Severe scoliosis
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT03986255