CSF/Serum Biomarkers in Predicting PND/Persistent Pain After Cesarean
CompletedNCT04271072
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This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
The aim is to investigate if inflammatory biomarkers in the blood and cerebrospinal fluid (CSF) are associated with the development of perinatal depression and/or persistent pain after cesarean delivery. This study will obtain CSF and blood samples in 70 parturients. All parturients will be assessed for perinatal depression and persistent pain, and the presence/absence of these outcomes will be correlated to changes in the inflammatory biomarkers within the samples collected. If present, consistent changes in biomarkers correlating with perinatal depression or persistent pain may be utilised as a predictive tool and facilitate early treatment for these conditions.
Study details
- Official title
- The Role of Cerebrospinal Fluid and Serum Inflammatory Biomarkers in Predicting Perinatal Depression and Persistent Pain After Cesarean Delivery
- Conditions
- Perinatal Depression
- Chronic Pain
- Interventions
- Sponsor
- Duke University
- Start date
- 2020-02-01
- Primary completion
- 2022-02-28
- Sex
- Female
- Age range
- from 18 Years to 40 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- United States
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * American Society of Anesthesiologists (ASA) class 2 and 3 * English speaking * 18 years or older * Singleton pregnancy * Gestational age \> 37 weeks * Scheduled cesarean delivery under spinal or combined spinal epidural anesthesia Exclusion Criteria: * Intravenous drug or chronic opioid use * Anti-depressant or anxiolytic drug use * Allergy to standard of care drugs * Cesarean delivery under general anesthesia or epidural anesthesia * Pre-eclampsia needing magnesium sulfate * Chronic PO/IV analgesic or glucocorticoids * History of chronic pain syndromes
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT04271072