Neurobiological Mechanisms of Stress in Youth With Chronic Widespread Pain
Active, not recruitingNot applicableNCT04488757
View the official record on ClinicalTrials.gov Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.
This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Chronic widespread pain (CWP) is a common chronic pain condition in youth and often associated with significant pain-related and psychosocial impairment. Understanding the neurobiological mechanisms that may underlie pediatric chronic pain and pain-related impairment can inform future treatments to ameliorate patients' suffering, making it a critical area of empirical investigation.
Study details
- Official title
- Neurobiological Mechanisms of Stress in Youth With Chronic Widespread Pain
- Conditions
- Chronic Widespread Pain
- Stress, Psychological
- Stress, Physiological
- Interventions
- Diagnostic test: functional Magnetic Resonance Imaging (fMRI)
- Other: Allostatic Load Composite
- Sponsor
- Boston Children's Hospital
- Collaborators
- National Center for Complementary and Integrative Health (NCCIH)
- Start date
- 2021-11-04
- Primary completion
- 2026-03-31
- Sex
- All
- Age range
- from 11 Years to 17 Years
- Healthy volunteers
- true
- Results posted
- No results posted in this snapshot
- Countries
- United States
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Chronic Widespread Pain (CWP) group: Inclusion Criteria: * Between ages 11-17 years * Referred to the Boston Children's Hospital Pain Treatment Service for evaluation of a CWP condition with duration \> 3 months * Right-handed Exclusion Criteria: * Inability to speak sufficient English to complete questionnaires * Severe cognitive impairment * Prescription steroidal (interference with cortisol measures) or psychotropic medication * Any other chronic pain diagnosis (e.g., migraines, abdominal pain, CRPS) * fMRI contraindications (e.g., dental appliances) Healthy Control (HC) group: Inclusion Criteria: * Between ages 11-17 years * Right-handed Exclusion Criteria: * Inability to speak sufficient English to complete questionnaires * Severe cognitive impairment * Prescription steroidal (interference with cortisol measures) or psychotropic medication * Any chronic pain diagnosis * Presence of documented chronic (\> 3 months) medical condition with an identifiable, organic cause (e.g., diabetes, cystic fibrosis) * fMRI contraindications (e.g., dental appliances)
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT04488757