Bone Marrow Concentrate (BMC) Injection in Intervertebral Discs
Unknown statusPhase 2, Phase 3NCT04559295
View the official record on ClinicalTrials.gov Recruiting status changes often. Contact the study team listed on ClinicalTrials.gov, and talk to your doctor before joining a study.
This study has no listed site in Canada in this snapshot. It is included as part of the worldwide chronic pain corpus.
Brief summary (from the registry)
Intradiscal delivery of bone marrow concentrate (BMC) into discs, facet, epidural space, and sacroiliac joints
Study details
- Official title
- Study of Bone of Marrow Concentrate (BMC) Injection in Discs, Facets, Sacroiliac Joints, and Epidural Space for Chronic Lower Back Pain With and Without Radiculopathy
- Conditions
- Low Back Pain
- Disc Disease
- Disc Degeneration
- Arthropathy Vertebrae
- Sacral Disorder
- Radiculopathy
- Spinal Stenosis
- Interventions
- Biological: Bone Marrow Concentrate
- Sponsor
- Stem Cures
- Start date
- 2018-11-21
- Primary completion
- 2020-03-19
- Sex
- All
- Age range
- from 18 Years to 60 Years
- Results posted
- No results posted in this snapshot
- Countries
- United States
- Total sites listed
- 1
Eligibility criteria
Show eligibility criteria (verbatim from the registry)
Inclusion Criteria: * A high index of suspicion for discogenic pain, i.e. painful degenerative discs with or without protrusions/herniations and facet/sacroiliac joint pain * Patients with mild to severe spinal stenosis * Patients with radiculopathy * Patients with disc extrusions * Patients with failed spinal fusion * Patients with mild to severe facet arthropathy * Patients with suspected sacroiliac joint disease * Age 18 to 60 years * Mild to severe loss of intervertebral disc height * Pain is not responsive to conservative treatment measures (oral medication, epidural steroid injections, physical therapy) * Pain persists for an extended period of time (i.e., at least 3 months) * High intensity zone (HIZ) in annular fissure or adjacent to annular fissure detected on T2 or STIR MRI * No evidence of contraindications to undergo procedure such as pregnancy, active infection, bleeding disorder, or metastatic cancer * English speaking Exclusion Criteria: * Spinal Deformity (Scoliosis \>20 degrees, Spondylolisthesis) * Sequestered fragments, severe thecal sac compression * Severe neurologic deficit * Non-English speaking * Bone marrow disorders * Immunosuppressed Patients * Patients with coagulopathy * Localized infection in the area of skin penetration * Spinal infection * Serious medical co-morbidities
Source: ClinicalTrials.gov (US National Library of Medicine), snapshot October 2026. Check the registry for current recruiting status. Record: https://clinicaltrials.gov/study/NCT04559295